Stem cell lines change over time, undergoing subtle genetic and epigenetic changes that can impact on their characteristics. Besides subtle culture-induced changes, there is also the risk of a simple mix-up or cross-contamination with other cells or adventitious agents as a result of a human error.

Newly derived, genetically modified, sub-cloned and extensively adapted stem cell lines benefit from periodical functional characterisation.
 
Characterisation services include:
  • Teratoma formation assay

  • In Vitro Differentiation

  • Gene expression analysis via PCR or qPCR

  • Protein expression analysis via flow cytometry or immunocytochemsitry

  • Karyotyping

  • DNA profiling

  • Mycoplasma testing.

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