Nanoparticles (green dots) targeting a cell surface receptor of a cancer cell.
Nanoparticles (green dots) targeting a cell surface receptor of a cancer cell.

Project keywords

Nanobiotechnology, Health, Antibody, Targeted delivery, Nanoparticle, Cancer, Cytotoxins

Project summary

The research projects are associated with targeted delivery of nanoparticles carrying cytotoxic drugs to cancer cells. Targeting the nanoparticles is accomplished through conjugation of monoclonal antibody fragments to nanoparticles of various compositions (including polymers, proteins and lipids). Antibodies targeting EGFR and VEGFR2 have been cloned and expressed as scFv antibody fragments. Other targets and antibodies to these targets are under investigation. The antibody fragments are subsequently conjugated to nanoparticles using a variety of chemistries and technologies. Antibody-conjugated nanoparticles are characterized by combinations of methodologies including plasmon surface resonance and fluorescence activated cell sorting to demonstrate binding to targets, and also a variety of in vitro and in vivo bioassays to demonstrate function.

Project contacts

Lead investigator Associate Professor Stephen Mahler
Research group Mahler Group
Contact email s.mahler@uq.edu.au

 

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