Approaches in Nanovaccinology
|Illustrative image of a modular capsomere with nanoparticles.|
Nanovaccinology, Vaccine, Nanotechnology, Capsomere, Nanoparticle, Microbial platform, Synthetic biology, Self-assembly, Nanomaterials, Nanobiotechnology, Health, Sustainability
Nanovaccinology encompasses the use of nanotechnology for the development of vaccine. Vaccine has a proud history as one of the most successful public health interventions to date. As vaccine development increasingly moves toward subunit composition, drawing on modern concepts of rational design and improved safety profile, novel adjuvant formulations and delivery systems are increasingly needed to boost the immunogenicity of these “minimalist” vaccines.
The Middelberg group is working at the intersection of vaccine engineering and nanotechnology, developing vaccine technology that can deliver vaccines at a speed and scale unattainable using currently approved vaccine manufacturing processes. The technology uses self-assemblies of viral capsid proteins that form a pentameric structure, called capsomere, as a delivery system to present antigenic modules from target diseases. Having viral molecular signature, modular capsomere induces potent immune response which could be boosted further by formulation with nanoparticles.
This research involves vaccine design, bioprocessing, and formulation. Vaccine design explores strategic and structural presentation of antigenic modules. Vaccine bioprocessing explores protein expression, purification, and process optimisation, as well as thorough protein characterisation from primary to quaternary states. Vaccine formulation explores the use of cutting-edge nanotechnology to create virus-inspired nanoparticles as adjuvant. Together this research would bring a vaccine technology that can radically change the way we fight infectious diseases, such as influenza, Group A Streptococcus, and Rotavirus.
|Lead investigator||Nani Wibowo|
|Research group||Middelberg Group|