Project keywords

iPSC, Ataxia-Telangiectasia, DNA damage, ATM, differentiation, Ageing, reporters, CRISPR

Project summary

Ataxia-Telangiectasia (A-T) is caused by mutations in the ATM kinase, a protein involved in DNA break repair and oxidative stress regulation. We have generated iPSC from human patients with A-T to study the degeneration of the hindbrain in this disease. We use CRISPR-Cas9 genome editing tools to correct and introduce mutations in ATM in IPSC and multi-omics and advanced imaging technologies to probe the underlying molecular processes.

Project contacts

Lead investigator Professor Ernst Wolvetang
Research group Stem Cell Engineering Group
Contact email


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