Dr Barbara Rolfe
Dr Barbara Rolfe

BSc, PhD UQ

Senior Research Fellow and Associate Group Leader

Contact

Telephone: +61 7 334 63856 Email: b.rolfe@uq.edu.au

Research: The Innate Immune System, Cancer Therapeutics and Biomedical Applications of Nanomaterials.

Dr Barbara Rolfe is an immunologist and cell biologist is an immunologist and cell biologist whose research focuses on myeloid cells and the innate immune response. Her research utilises animal models of disease to investigate key questions in biomedical research: 1) biomedical applications of nanomaterials, and how the immune response to nanoparticles influences their in vivo fate, and 2) the application of complement-targeting drugs as cancer therapeutics. 

Dr Rolfe’s work has been presented widely at national and international forums including the Leukocyte Biology Conference (Kansas City, USA, 2011), International Complement Therapeutics Conferences (Kos, 2013 and Crete, 2015) and ICBNI Conference (Shanghai China, Sept 2013).  She has international collaborations, including with The Universities of Edinburgh and Bristol (UK), Wuhan (China), Navarra (Spain) and the Institute of Biofunctional Polymer Materials (Dresden, Germany).

During her research career Dr Rolfe has received funding from numerous organisations, including National Health and Medical Research Council, National Heart Foundation and Queensland Cancer Council.  She is a co-inventor on a patent relating to complement therapeutics in cancer.

Key Publications

Mooney JE, Summers KM, Gongora M, Grimmond S, Campbell JH, Hume DA, Rolfe BE (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunol Cell Biol 92(6):518-26.

Rolfe B, Blakey, I, Squires, O; Peng H, Boase N, Alexander C Parsons P, Boyle G, Whittaker, A, Thurecht K (2014). Multi-modal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo.  J Am Chem Soc. 136:2413-9. Manthey HD,

Thomas AC, Shiels IA, Zernecke A, Woodruff TM, Rolfe B*, Taylor SM* (2011). Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 25(7):2447-55. * Shared senior author. 

Mooney JH, Rolfe BE, Osborne GW, Sester DP, van Rooijen N, Campbell GR, Hume DA, Campbell JH (2010). Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response. Am J Pathol 176: 369-380. 

Le S-J, Gongora M, Zhang B, Grimmond SM, Campbell GR, Campbell JH, Rolfe BE (2010). Gene Expression Profile of the Fibrotic Response in the Peritoneal Cavity. Differentiation 79:232-43.

Recent Publications

Full list of publications available at UQ eSpace.

Dr Barbara Rolfe section

Rolfe: Research Projects

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