A cortical brain organoid
A cortical brain organoid

Project keywords

iPSC, optogenetics, neuronal connectivity, neurons, differentiation, Ageing, organoids, CRISPR

Project summary

In this project variously functionlised hydrogels as well as conventional stirred bioreactors will be used to generate brain organoids from control, neurological disease and artificially aged human iPSC. Various optogenetic tools as well as reporter gene technology will be deployed to interrogate neuronal  connectivity and the gene regulatory networks that underlie disease and ageing. 

Project contacts

Lead investigator Professor Ernst Wolvetang
Research group Stem Cell Engineering Group
Contact email e.wolvetang@uq.edu.au

 

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