Toxoid vaccines are used to prevent disease caused by pathogenic clostridia
Toxoid vaccines are used to prevent disease caused by pathogenic clostridia

Project keywords

Systems Biology, Health, Manufacturing, Toxoid, Clostridia, Livestock, Vaccine, Proteomics, Metabolomics, Transcriptomics

Project summary

Toxoid vaccines are used routinely in the livestock industry to prevent animal-disease caused by pathogenic clostridia. Vaccines are produced using batch fermentation processes, which have undergone limited optimization over the past five decades. Low titres and frequent batch failures greatly affect capital utilization and represent a significant cost factor. This project uses high-throughput chemistry (omics) to produce ‘molecular maps of fermentation’, which will be used to design a new generation of superior fermentation processes. Achieving the aims will be of direct relevance to diagnose causes of batch failure (e.g., raw material failures) and engineer productive, high density fermentation for the production of toxins use in vaccine formulation to prevent multiple animal diseases.

Project contacts

Lead investigator Dr Esteban Marcellin, Professor Lars Nielsen
Research group AIBN Systems & Synthetic Biology
Contact email e.marcellin@uq.edu.au

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