Schematic outline of MALDH-based adjuvants-antigen combined system.
Schematic outline of MALDH-based adjuvants-antigen combined system.

Project keywords

Nanomaterials, nanobiotechnology, health, vaccine, combination, adjuvants, Th1 and Th2, nanoparticle, dendritic cells, immune response, cytokines

Project summary

Current vaccines can prevent many infectious diseases but are ineffective against cancers and diseases such as malaria and HIV. This project will use a novel nanoparticle vaccine delivery platform to regulate the function of dendritic cells (DCs), a key player for immune responses. Antigens and adjuvants that boost the immune response (such as CpG, polyI:C, LPS) and siRNAs will be assembled onto layered double hydroxide (LDH) nanoparticles and their effects on DC-mediated T cell activation will be investigated. This project will help develop more efficient adjuvant combinations to enhance immune responses, enabling the design of new generation vaccines.

Project contacts

Lead investigator Associate Professor Zhi Ping (Gordon) Xu
Research group Nanomac
Contact email gordonxu@uq.edu.au

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