Professor Kirill Alexandrov
Professor Kirill Alexandrov

PhD EMBL
ARC Future Fellow and Group Leader

Contact

Telephone: +61 7 3346 2017 Email: k.alexandrov@imb.uq.edu.au

Research: Next-generation technologies for protein research

Professor Kirill Alexandrov is a co-founder of successful biotechnology company Jena Bioscience and credited with establishing the Dortmund Protein Production Facility at the Max-Planck Institute. He introduced high−throughput molecular cloning technology to the UQ Protein Expression Facility. Professor Alexandrov has secured three Australian Research Council (ARC) and two National Health and Medical Research Council (NHMRC) project and program grants since 2008; and been awarded an ARC Australian Postdoctoral Fellowship and Future Fellowship.

International links

Professor Alexandrov is a co-founder of successful biotechnology company Jena Bioscience and has retained close collaborative links with the Dortmund Protein Production Facility at the Max-Planck Institute. He has close collaborations with Brisbane biotechnology company Bioproton LLC and Perth biotechnology company Phylogica.

Memberships, patents and funding

Professor Alexandrov has raised about $22 million in funding since 2008; secured three Australian Research Council and two National Health (ARC) and Medical Research Council (NHMRC) grants since 2008; and been awarded an ARC Australian Postdoctoral Fellowship and Future Fellowship. He filed six patents, including one which has reached international phase.

Awards and plenaries

Professor Alexandrov has received more than 30 invitations to speak at national and international conferences. They include:

  • 2011 PepTalk, US. Invited Plenary Speaker, Chair of round table discussion
  • 2011 9th Matsuyama International Symposium on Cell-Free Sciences, Japan. Invited Plenary Speaker
  • 2011 FASEB Summer Research Conferences on Protein Lipidation, Signaling, and Membrane Domains, US. Invited Plenary Speaker
  • 2011 Choroideremia disease Workshop, France. Invited Plenary Speaker
  • 2011 9th Australian Peptide Conference, Australia. Invited Plenary Speaker

In 2004, Professor Alexandrov was awarded Germany’s highest career development fellowship, the Heisenberg Award.

Key publications in the past five years

Stein V. and Alexandrov K. Protease-based synthetic sensing and signal amplification. PNAS, 2014 In press,  Accepted 26.09.2014

Kovtun O., Tillu VA., Jung WR., Leneva N., Ariotti N., Chaudhary N.,Mandyam RA, Ferguson C., Harrop SJ., Alexandrov K., Parton RG and Collins BM. Structural insights into the organisation of the cavin membrane coat complex. Dev. Cell. In press. Accepted 03.10.2014

Martin S, Papadopulos A, Tomatis VM, Sierecki E, Malintan NT, Gormal RS, Giles N, Johnston WA, Alexandrov K, Gambin Y, Collins BM, Meunier FA.  Increased polyubiquitination and proteasomal degradation of a munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis.  Cell Rep. 2014 Oct 9;9(1):206-18

Tnimov Z, Abankwa D, Alexandrov K. RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation. Biochem Biophys Res Commun. 2014 Oct 3;452(4):967-73. Kovtun O, Mureev S, Jung W, Kubala MH, Johnston W, Alexandrov K. (2011) Leishmania cell-free protein expression system. Methods 55(1), 58-64.

Kovtun O, Mureev S, Johnston W, Alexandrov K. (2010) Towards the construction of expressed proteomes using a Leishmania tarentolae based cell-free expression system. PLOS One 5, e14388.

Mureev S, Kovtun O, Nguyen UTT, Alexandrov K. (2009) Species-independent translational leaders enable the rapid development of novel cell-free expression systems. Nature Biotechnology 27, 747-752.

*Joint appointment with UQ’s Institute for Molecular Biosciences. Visit Professor Alexandrov's IMB site here.

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