Dr Nani Wibowo
|Dr Nani Wibowo|
Dr Nani Wibowo is a research officer leading the team working on engineering virus-like particle (VLP) and its subunits (capsomere) for rapidly-manufactured and low-cost vaccines.
The technology uses VP1 structural protein from murine polyomavirus. An antigenic module from a target disease is introduced into the surface-exposed loop of VP1 at the DNA level, expressed efficiently in Escherichia coli and purified using scalable units. The target antigenic module is presented with a viral molecular signature when modular VP1 proteins assemble into capsomeres or VLPs, inducing potent immune response.
Dr Wibowo believes this modular vaccine design approach has potential to address emergent and numerous other diseases at a scale and speed that is unattainable using existing technology.
Chuan YP, River-Hernandez T, Wibowo N, Connors NK, Wu Y, Hughes F, Lua LHL, Middelberg APJ. (2013) Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnology and Bioengineering. doi: 10.1002/bit.24907.
Wibowo N, Chuan YP, Lua LHL, Middelberg APJ. (2012) Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chemical Engineering Science. In Press.
Middelberg APJ, Rivera-Hernandez T, Wibowo N, Lua LHL, Fan YY, Magor G, Chang C, Chuan YP, Good M, Batzloff M. (2011) A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine (Special Issue: Vaccine Technology III) 29(41),7154-7162.
Wibowo N, Wang MJ, Chang CC, Lee CK. (2008). The design of novel scaffolds by integrating microbial cellulose onto plasma treated polypropylene, in Advanced Materials Research: Multi-Functional Materials and Structures, Parts I and II. Lau AKT, Lu J, Varadan VK, Chang FK, Tu JP, Lam PM, (Eds.), (pp 1371-1374) Stafa-Zurich: Trans Tech Publications Ltd.
Wibowo N, Setyadhi L, Wibowo D, Setiawan J, Ismadji S. (2007) Adsorption of benzene and toluene from aqueous solutions onto activated carbon and its acid and heat treated forms: Influence of surface chemistry on adsorption. Journal of Hazardous Material 146, 237-242.
PhD (Chemical Engineering), UQ
Master of Science in Engineering (Chemical Engineering), National Taiwan University of Science and Technology, Taiwan
Bachelor of Engineering (Chemical Engineering), Widya Mandala Catholic University Surabaya, Indonesia