Tumour detection using Cu-64 labelled polymer in mouse melanoma model.
Tumour detection using Cu-64 labelled polymer in mouse melanoma model.

Project keywords

Nanomaterials, Nanobiotechnology, Health, Nanomedicine, Molecular imaging, Theranostics, Drug delivery, Gene delivery, siRNA, Nanotechnology, Polymer

Project summary

Recent synthetic advances that facilitate control over polymer structure and functionality have led to the advent of polymer theranostics; devices capable of simultaneously diagnosing disease, delivering a therapy and monitoring the treatment and disease progression. While the potential application of such devices is tremendous, in vivo monitoring remains a significant scientific challenge. While the ultimate aim in polymer theranostics is the development of a multi-modal, multi-functional, biodegradable delivery device with the possibility of facile conjugation of therapeutics, imaging agents and targeting moieties, current methodologies are plagued by poor drug loading, inefficient cell uptake, targeting inefficiencies, synthetic complexities or a combination of all of these factors. This project explores the design, synthesis and preclinical testing of polymeric theranostics that incorporate various molecular imaging modalities as a means of monitoring drug and gene therapies.

Project contacts 

Lead investigator Dr Kristofer Thurecht
Research group Whittaker Group
Contact email k.thurecht@uq.edu.au

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