Early amyloid plaque formation in iPSC derived neurons in vitro.
Early amyloid plaque formation in iPSC derived neurons in vitro.

Project keywords

iPSC, Reprogramming, differentiation, epigenetics, Ageing, neurons, organoids, CRISPR

Project summary

In this project CRISPR technology will be used to engineer accellerated ageing models in human iPSC that subsequently will be subjected to neuronal differentiation in 2D and 3D (brain organoid) settings. Simultaneously isogenic somatic cells will be directly reprogrammed into equivalent neuronal cell types to probe the genetic and epigenetic drivers of in vitro observable ageing phenomena. 

Project contacts

Lead investigator Professor Ernst Wolvetang
Research group Stem Cell Engineering Group
Contact email e.wolvetang@uq.edu.au

 

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