Professor Wolvetang is currently seeking highly motivated students to undertake research projects.

Wolvetang Group PhD Projects section

Induced pluripotent stem cells from individuals with Down syndrome

Title PhD project: Induced pluripotent stem cells from individuals with Down syndrome to identify how and when overexpression of chromosome 21 genes deregulates early cell fate decisions during brain development and test whether th...

Modelling and engineering cilliopathies with human iPSC

Title PhD project: Modelling and engineering cilliopathies with human iPSC Hypothesis: CRSIPR mediated genome editing of cilia genes in human IPSC can be used to interrogate cilia function in early human dev...

Modelling the neuromuscular junction with iPSC derived cell types of control and ALS patients

Title PhD project: Modelling the neuromuscular junction with iPSC derived cell types of control and ALS patients. Hypothesis: Building In vitro iPSc derived motor neuron-muscle circuits will reveal disease m...

Understanding tRNA synthase deficiency induced leukoencephalopathies

Title PhD project: Understanding tRNA synthase deficiency induced leukoencephalopathies. Hypothesis: NextGeneration Sequencing coupled with CRISPR mediated functional validation in patient-derived iPSC can...

Using in vitro generated iPSc derived neuronal networks to understand the epigenetic basis of human memory formation

Title PhD project: Using in vitro generated iPSc derived neuronal networks to understand the epigenetic basis of human memory formation. Hypothesis: In vitro iPSc derived neurons can be used to study how non-CG methylation a...

Delivery of iPSC derived cerebellar cells for treatment of ataxias

Title PhD project: Delivery of iPSC derived cerebellar cells for treatment of ataxias. Hypothesis: immature human IPSC derived cerebellar cell types can be safely delivered into the hindbrain and functional...

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