Associate Group Leaders
AIBN is nurturing the next generation of scientific leaders.
AIBN research leaders
B App Sci (Chem) (Hons) QUT, PhD (Polymer Chemistry) QUT
Principal Research Fellow and Associate Group Leader
Telephone: +61 7 334 63869 Email: email@example.com
Research: Rational design, synthesis and self assembly of functional polymers and nanomaterials for nanofabrication, sensors and biomedical imaging agents
Associate Professor Idriss Blakey is an Australian Research Council (ARC) Future Fellow (2010-2014) and a chief investigator on an ARC Linkage project in partnership with the Dow Chemical Company. His contributions to polymer science have been published by leaders such as Wiley, the American Chemical Society and the Royal Society of Chemistry. Associate Professor Blakey is a regular reviewer and adjudicative reviewer for more than 20 journals, as well as for granting bodies including the ARC, Wellcome Trust, US Department of Energy and the Australian Synchrotron. He has been lead chief investigator on three ARC Discovery grants and chief investigator on three ARC Linkage projects grants in partnership with Intel Corporation and Sematech (a consortium of leading semiconductor companies). Associate Professor Blakey has also been a recipient of a Queensland Government Smart State Fellowship, working with Sematech on developing advanced polymers for use in computer chip manufacture. He has one fully granted patent, as well as patents at the PCT and provisional stages.
Rolfe, B. E.; Blakey, I.; Squires, O.; Peng, H.; Boase, N. R. B.; Alexander, C.; Parsons, P. G.; Boyle, G. M.; Whittaker, A. K.; Thurecht, K. J., Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo. Journal of the American Chemical Society 2014, 136 (6), 2413-2419.
Keen, I.; Cheng, H.-H.; Yu, A.; Jack, K. S.; Younkin, T. R.; Leeson, M. J.; Whittaker, A. K.; Blakey, I., Behavior of Lamellar Forming Block Copolymers under Nanoconfinement: Implications for Topography Directed Self-Assembly of Sub-10 nm Structures. Macromolecules 2014, 47 (1), 276-283.
Dey, P.; Zhu, S.; Thurecht, K. J.; Fredericks, P. M.; Blakey, I., Self assembly of plasmonic core-satellite nano-assemblies mediated by hyperbranched polymer linkers. Journal of Materials Chemistry B 2014, 2, 2827-2837.
Chuang, Y.-M.; Jack, K. S.; Cheng, H. H.; Whittaker, A. K.; Blakey, I., Using Directed Self Assembly of Block Copolymer Nanostructures to Modulate Nanoscale Surface Roughness: Towards a Novel Lithographic Process. Advanced Functional Materials 2013, 23 (2), 173-183.
Blakey, I.; Merican, Z.; Thurecht, K. J., A Method for Controlling the Aggregation of Gold Nanoparticles: Tuning of Optical and Spectroscopic Properties. Langmuir 2013, 29 (26), 8266-8274.
Lawrie, K. J.; Blakey, I.; Blinco, J. P.; Cheng, H. H.; Gronheid, R.; Jack, K. S.; Pollentier, I.; Leeson, M. J.; Younkin, T. R.; Whittaker, A. K., Chain scission resists for extreme ultraviolet lithography based on high performance polysulfone-containing polymers. Journal of Materials Chemistry 2011, 21, 5629-5637.
- 13th Pacific Polymer Conference, Kaoshiung, Taiwan, November 2013.
- 6th International conference on Advanced Materials and Nanotechnology (AMN-6), Auckland, February 2013
- 13th Australasian Polymer Summer School, December 2011
- Korea-Australian Symposium on Advanced Polymer Materials, Gumi Korea, November 2011
- RadTech Asia, Yokohama Japan, June 2011
- 24th Australian Polymer Symposium (ECR keynote), February 2011
- Polymer Materials Performance, Degradation and Optimization Symposium, Pacifichem 2010, Hawaii, US, December 2010Smart Surfaces & Cell Therapy, November 2010
- Imaging Symposium–Queensland and Washington Alliance Group, August 2009
- Sematech's Resist Advisory Group-Immersion Technology Advisory Group meeting, Austin, Texas, August 2004 and 2005
BE (Polymer) QUST, PhD FDU, China
ARC Future Fellow and Associate Group Leader
Telephone: +61 7 3346 4163 Email: firstname.lastname@example.org
Research: Engineered Polymer Scaffolds for Controlled Proliferation and Differentiation of Stem Cells
Dr Zhongfan Jia is an Australian Research Council (ARC) Future Fellow (2014-2017). Dr Jia obtained his PhD in polymer chemistry and physics. He joined AIBN as a UQ Postdoctoral Research Fellow in 2009. Since then, he has been working in Prof. Monteiro’s group on complex polymer design and synthesis, polymer functionalization for biomedical applications, and continuously publishing in leading chemistry and polymer journals, such as Nat. Commun., Angew Chemie Int. Ed. JACS, Macromolecules and Biomacromolecules etc. He regularly reviews journal articles and also writes reviews, highlights and book chapters. He has also been awarded UQ ECR Award (2010) and UQ-Trans-Pacific Fellowship (2012). Prior to joining AIBN, he worked as a postdoctoral research fellow in Centre for Advanced Macromolecular Design (CAMD) at University of New South Wales. His current research topics are design polymer nanostructured materials for stem cells application, imaging, and supercapacitors.
Jia ZF, Bobrin VA, Truong NP, Gillard M, Monteiro MJ. (2014) Multifunctional Nanoworms and Nanorods through a One-Step Aqueous Dispersion Polymerization. J. Am. Chem. Soc. 136, 5824–5827.
Gu WY, Jia ZF, Truong NP, Prasadam I, Xiao Y, Monteiro MJ. (2013) Polymer Nanocarrier System for Endosome Escape and Timed Release of siRNA with Complete Gene Silencing and Cell Death in Cancer Cells. Biomacromolecules 14, 3386-3389.
Truong NP, Gu WY, Prasadam I, Jia ZF, Monteiro MJ. (2013) An influenza virus-inspired polymer system for the timed release of siRNA. Nat. Commun. 4, 1902, 1-7.
Lu DR, Jia ZF, Monteiro MJ. (2013) Synthesis of Alkyne Functional Cyclic Polymers by One-pot Thiol-ene Cyclization. Polym. Chem. 4, 2080-2089.
Jia ZF, Truong NP, Monteiro MJ. (2013) Reversible polymer nanostructures by regulating SDS/PNIPAM binding. Polym. Chem., 4, 592-599.
Jia ZF, Lonsdale DE, Kulis J, Monteiro MJ. (2012) Construction of a 3-Miktoarm Star from Cyclic Polymers. ACS Macro Lett. 1, 780-783.
Jia ZF, Bell CA, Monteiro MJ. (2011) Directing the pathway of orthogonal ‘click’ reactions by modulating copper-catalytic activity. Chem. Commun. 47, 4165-4167.
Jia ZF, Bell CA, Monteiro MJ. (2011) Rapid and Highly Efficient Functionalization of Polymer Bromide End-Groups by SET-NRC. Macromolecules 44, 1747-1751.
BSc Chem Eng, PhD UQ
Associate Group Leader
Telephone: +61 7 33463158, Email: email@example.com
Most chemicals are currently derived from fossil feedstocks. Dr Marcellin’s research is trying to shift production of these chemicals to more sustainable alternatives; by using living cells as cell factories we are converting bio-based feedstocks into chemicals and fuels. Our research goes beyond conventional sugars as fermentation feedstocks: we are using gasified waste as a more sustainable alternative. Gas fermentation not only does not compete with arable land or the food chain but is also readily available at a low cost. To produce value added chemicals however, cells need to be metabolically engineered and new processes need to be developed and optimized.
To achieve this goal, we use systems metabolic engineering, a powerful novel approach which guides the improvement of biological processes by identifying gene targets for engineering. Using a knowledge driven approach that takes advantage of the growth in high throughput omics (genomics, transcriptomics, metabolomics proteomics and phosphoproteomics) coupled with mathematical models, we can understand, predict, and optimize the properties and behaviour of cells (e.g. identification of gene targets for knock out/up-regulation). The combination of these experimental and computational tools can also be used to drive yields and productivities close to capacity. Generally, these improvements require various iterative rounds. Thus, the models are constantly refined and validated using biological (omics) data leading to further rounds of metabolic engineering, which in the end, drive cells close to the maximum theoretical yield.
In collaboration with leaders in the industry, we are currently applying systems metabolic engineering to produce propionic acid, enhance clostridial vaccine yields and to increase the production scope of gas fermenting bacteria.
Marcellin E, Steen JA, Nielsen LK (2014) Insight into hyaluronic acid molecular weight control. Applied Microbiology and Biotechnology 98: 6947-56. PMID: 24957250.
Licona-Cassani C, Lim SA, Marcellin E, Nielsen LK (2014) Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome. Molecular and Cellular Proteomics 13: 1219-1230. PMID: 24615062
Marcellin E, Licona-Cassani C, Mercer TR, Palfreyman RW, Nielsen LK (2013) Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach. BMC Genomics 14:699. PMID: 24118942. Open access
Marcellin E, Mercer TR, Licona-Cassani C, Palfreyman RW, Dinger M, Steen JA, Mattick JS, Nielsen LK (2013) Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics 14:15. PMID: 23324121. PMC3610266
Marcellin E, Chen W, Nielsen LK (2010) Understanding plasmid effect on hyaluronic acid molecular weight produced by Streptococcus equi subsp. zooepidemicus. Metabolic Engineering 12: 62–69. PMID: 19782148.
Chen WY, Marcellin E, Nielsen LK (2009) Hyaluronan molecular weight is controlled by UDP-N- acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem 284:18007-14. PMID: 19451654.
BSc (Hons) UQ, PhD UQ
ARC Future Fellow and Associate Group Leader
Telephone: +61 7 3346 3864 Email: firstname.lastname@example.org
Research: Design and synthesis of architectural polymers applied to molecular imaging and drug delivery in nanomedicine
Associate Professor Kris Thurecht is an Australian Research Council (ARC) Future Fellow with appointments at AIBN and UQ’s Centre for Advanced Imaging. Associate Professor Thurecht has been recognised for scientific excellence with a 2012 Queensland Young Tall Poppy Science Award and a 2010 UQ Foundation Research Excellence Award for his work in developing polymer ‘theranostics’. Since obtaining his PhD in 2005, he has been the recipient of four competitive national and international fellowships including an Australian Postdoctoral Research Fellowship in 2008; and simultaneous awarding of a British Ramsay Centenary Fellowship and an 1851 Research Fellow in the UK in 2007. He has contributed scientific and review articles to various leading journals in his field, including invited articles in the Emerging Young Investigator issue of Chemical Communications and a Young Talent article in Macromolecular Chemistry and Physics. Associate Professor Thurecht has been chief investigator on grants from various funding bodies, including ARC Discovery grants; ARC Linkage Grants, with international pharmaceutical company Eli Lilly; a National Health and Medical Research Council (NHMRC) grant; and funding from the Prostate Cancer Foundation of Australia. He is co-inventor on two patents.
- 245th American Chemical Society National Meeting and Exposition, April 7-11, 2013, New Orleans, US.
- 12th International Conference on Frontiers of Polymers and Advanced Materials, December 8-12, 2013, Auckland, New Zealand.
- 33rd Australasian Polymer Symposium, February, 2012, Hobart, Australia.
- Korea-Australian Symposium on Advanced Polymer Materials, November 2011, Gumi, Korea.
- International Nanomedicine Conference, July 3-5, 2011, Sydney, Australia.
- International Nanomedicine Conference, June 30 - July 2, 2010, Sydney, Australia.
Key publicationsRolfe, Barbara E., Blakey, Idriss, Squires, Oliver, Peng, Hui, Boase, Nathan R. B., Alexander, Cameron, Parsons, Peter G., Boyle, Glen M., Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. Journal of the American Chemical Society, 136 6: 2413-2419.
Boase, Nathan R. B., Blakey, Idriss, Rolfe, Barbara E., Mardon, Karine and Thurecht, Kristofer J. (2014) Synthesis of a multimodal molecular imaging probe based on a hyperbranched polymer architecture. Polymer Chemistry, 5 15: 4450-4458.
Puttick A, Davis AL, Butler K, Irvine DJ, Licence P, Thurecht KJ. (2013) The influence of domain segregation in ionic liquids upon controlled polymerisation mechanisms: RAFT polymerisation. Polym Chem 4, 1337-1344.
Boase NRB, Blakey I, Thurecht KJ. (2012) Molecular Imaging with Polymers. Polymer Chemistry 3(6), 1384-1389.
Ardana, Aditya, Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) PEG-based hyperbranched polymer theranostics: optimizing chemistries for improved bioconjugation. Macromolecules, 47 15: 5211-5219.
Thurecht KJ, Blakey I, Peng H, Squires O, Hsu S, Alexander C, Whittaker AK. (2010) Functional Hyperbranched Polymers: Toward Targeted in Vivo 19F Magnetic Resonance. Journal of the American Chemical Society 132(15), 5336-5337.
BSc, PhD UQ
Senior Research Fellow and Associate Group Leader
Telephone: +61 7 334 63856 Email: email@example.com
Research: The Innate Immune System, Cancer Therapeutics and Biomedical Applications of Nanomaterials.
Dr Barbara Rolfe is an immunologist and cell biologist is an immunologist and cell biologist whose research focuses on myeloid cells and the innate immune response. Her research utilises animal models of disease to investigate key questions in biomedical research: 1) biomedical applications of nanomaterials, and how the immune response to nanoparticles influences their in vivo fate, and 2) the application of complement-targeting drugs as cancer therapeutics.
Dr Rolfe’s work has been presented widely at national and international forums including the Leukocyte Biology Conference (Kansas City, USA, 2011), International Complement Therapeutics Conferences (Kos, 2013 and Crete, 2015) and ICBNI Conference (Shanghai China, Sept 2013). She has international collaborations, including with The Universities of Edinburgh and Bristol (UK), Wuhan (China), Navarra (Spain) and the Institute of Biofunctional Polymer Materials (Dresden, Germany).
During her research career Dr Rolfe has received funding from numerous organisations, including National Health and Medical Research Council, National Heart Foundation and Queensland Cancer Council. She is a co-inventor on a patent relating to complement therapeutics in cancer.
Mooney JE, Summers KM, Gongora M, Grimmond S, Campbell JH, Hume DA, Rolfe BE (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunol Cell Biol 92(6):518-26.
Rolfe B, Blakey, I, Squires, O; Peng H, Boase N, Alexander C Parsons P, Boyle G, Whittaker, A, Thurecht K (2014). Multi-modal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. J Am Chem Soc. 136:2413-9. Manthey HD,
Thomas AC, Shiels IA, Zernecke A, Woodruff TM, Rolfe B*, Taylor SM* (2011). Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 25(7):2447-55. * Shared senior author.
Mooney JH, Rolfe BE, Osborne GW, Sester DP, van Rooijen N, Campbell GR, Hume DA, Campbell JH (2010). Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response. Am J Pathol 176: 369-380.
Le S-J, Gongora M, Zhang B, Grimmond SM, Campbell GR, Campbell JH, Rolfe BE (2010). Gene Expression Profile of the Fibrotic Response in the Peritoneal Cavity. Differentiation 79:232-43.
BSc (Hons I) UQ, PhD (Molecular Biology) UQ
Queensland Government Accelerate Fellow and Associate Group Leader
Telephone: +61 7 334 63958, Email: firstname.lastname@example.org
Dr Vickers works in the fields of isoprenoid biology/metabolic regulation/engineering, carbohydrate metabolism/engineering, and beer systems biology. These diverse areas are linked though understanding fundamental biology and applying this understanding to industrial bioprocesses. In particular, she has an interest in using biology to replace current industrial practices (largely based on finite petrochemical resources) with sustainable, environmentally friendly approaches. To this end, she uses the tools of systems and synthetic biology for metabolic engineering of microbes.
Dr Vickers has made seminal contributions to: understanding the role of isoprenoids in plant biochemistry/physiology; elucidating the genetic, molecular and biochemical control isoprene emission; and understanding/engineering sucrose utilization in industrial microbes. She has also developed many enabling tools for molecular biology/synthetic biology in both plants and microbes (transformation vectors, expression control systems, chromosomal integration systems, reporter systems, etc.).
Dr Vickers has research programs and student research projects available in the following areas (see here for details):
- Isoprenoid Pathway Engineering
- Isoprenoid Biofuels and Industrial Biochemicals
- Tools for Synthetic Biology
- Synthetic Biology Circuit Construction
- Beer Systems Biology
- Feedstock Pathway Engineering
Dr Vickers is very active in science education, outreach and career advice for early career scientists. She has been invited to act as an advisor on synthetic biology (as an emerging technology) for both the Australian Federal Government and the Institute on Science for Global Policy (an American-based organisation).
Vickers, C.E.*; Bongers, M.; Qing, L.; Delatte, T.; Bouwmeester, H. (2014) Metabolic engineering of volatile isoprenoids in plants and microbes. Plant Cell & Environment 37(8):1753-1775 (invited)
Williams, T.C.; Nielsen, L.K.; Vickers, C.E.* (2013) Engineered quorum-sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae. ACS Synthetic Biology 2(3):136-149
Vickers, C.E.*; Blank, L.M.; Kroemer, J.O. (2010) Chassis cells for industrial biochemical production. Nature Chemical Biology 6(12):875–877
Vickers, C.E.*; Gershenzon, J.; Lerdau, M.; Loreto, F. (2009) A unified mechanism of action for volatile isoprenoids in plant abiotic stress. Nature Chemical Biology 5:283-291 (invited)
Vickers, C.E.*, Possell, M.; Cojocariu, C.; Velikova, V.; Laothawornkitcul, J.; Ryan, A.; Mullineaux, P.M.; Hewitt, C.N. (2009) Isoprene synthesis protects transgenic plants from oxidative stress. Plant, Cell & Environment 32:520-531
- Young Tall Poppy Science Award (Australian Institute of Policy & Science; 2014)
- Queensland Government Accelerate Fellowship (2014)
- UQ Foundation Research Excellence Award (The University of Queensland; 2013)
- Alfred P. Sloan Foundation Honorarium (Society for Risk Analysis Conference; 2012)
- Australian Academy of Science Travel Fellowship: Scientific Visit to Korea (2010)
- Queensland Government Smart Futures Fellowship (2010)
- Inaugural Science Communication Award, Gordon Research Conference on Biogenic Volatiles and the Atmosphere (2007)
Molecular Biology Tools
- Dual gene expression cassette vectors with antibiotic selection markers for yeast PMID: 24161108
- 2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis PMID: 23968454
- Knock-in/Knock-out (KIKO) vectors for rapid integration of large DNA sequences onto E. coli chromosomes PMID: 23799955
- Synthetic circuits for quorum-based cell-density-dependent signalling/responses in yeast Link: ACS Snthetic Biology
- Transferable sucrose utilization modules for E. coli PMID: 21907272
- sXynA: A synthetic xylanase reporter gene for functional analysis Link
- pGFPGUSPlus: a dual reporter gene binary vector for plant transformation Link
Outreach: Synthetic Biology (Video Links)
From a petrochemical to a biochemical economy. Click here to view.
A video prepared for the 2013 University of Queensland Foundation Research Excellence Awards, explaining Dr Vickers’ synthetic biology jet fuel research.
What is Synthetic Biology? Click here to view.
An animated cartoon aimed at non-scientists, explaining what synthetic biology is. Developed with the Royal Institution of Australia and supported by the Australian Government Department of Innovation, Industry, Science and Research.
Synthetic Biology: What does it mean for you? Click here for videos.
A public forum explaining what synthetic biology is and engaging with the public on legislative and ethical issues surrounding synthetic biology. Presented at The Science Exchange, Royal Institution of Australia and supported by the Australian Government Department of Innovation, Industry, Science and Research.
Club Cosmos: Synthetic Biology in the Pub Part 1 and Part 2
A pub discussion of synthetic biology at Forresters Hotel, Surry Hills, Sydney. Presented by Club Cosmos (Cosmos Magazine) and supported by the Australian Government Department of Innovation, Industry, Science and Research.
RiAus PDPlus: Synthetic Biology - Creating life in the lab
Aimed at secondary school teachers as a teaching assistance tool, this is an everyday language explanation of what synthetic biology is, what training you need to do it, and what the industry is like in Australia and across the world. Presented at The Science Exchange, Royal Institution of Australia and supported by the Australian Government Department of Innovation, Industry, Science and Research.
BSc (Hons) University of Sydney, PhD (Plant and Microbial Sciences) John Innes Centre, UKARC DECRA Fellow and Associate Group Leader
Telephone: +61 7 3346 3179 Email: email@example.com
Research Summary: Understanding and exploiting supramolecular self-assembly of protein-based nanoparticles
Dr Frank Sainsbury is an ARC Discovery Early Career Research Awardee investigating innovative approaches to developing novel vaccines and nano-scale therapeutic vehicles. He is using biomolecular engineering of virus-like particles (VLPs) and peptide-stabilised nano-scale emulsions to create protein-based nanoparticles with sophisticated properties for intracellular antigen delivery and cell-specific targeting of drugs and imaging agents. These advanced applications are underpinned by fundamental research in molecular self-assemble of VLPs and the interfacial properties of peptide-stabilised emulsions. Deep understanding of the structure-function relationship of both particle types guides the development of purification and assembly processes as well as enabling their controlled functionalization.
Dr Sainsbury’s background is in the plant-based production of pharmaceutically relevant proteins, principally VLPs, and is a 2012 recipient of the UK Biotechnology and Biological Sciences Research Council (BBSRC), Innovator of the Year award in recognition of his work in plant-based vaccine production and his role in achieving impact for this ground breaking technology. The granted patent resulting from this work is licensed for the production of influenza vaccines currently in late-stage clinical trials and underpins a recent £5M UK Government (BBSRC) investment in a facility to exploit the technology. Dr Sainsbury carried out industry-funded postdoctoral work on the manufacture and engineering of VLPs as drug delivery vehicles and inorganic particle templates. This was followed by a stint at Laval Univeristy, Canada where Dr Sainsbury is now an Adjunct Professor and postgraduate student supervisor. His work there pioneered the use of synthetic biology to modify whole plant hosts for recombinant protein production and protein engineering in plant biotechnology.
Dr Sainsbury has an excellent record of publication in biotechnology, bioengineering and bionanotechnology. He is an inventor on 5 patents relating to high-yield protein production in plants and VLP engineering and is regularly invited to contribute reviews on these topics. To date his research has been supported by an Australian Research Council (DECRA), a UQ ECR Grant, UniQuest Pathfinder and Contract Research grants, and the Australian Nuclear Science and Technology Organisation.
Catrice EVB, Sainsbury F (2015) Assembly and purification of polyomavirus-like particles from plants. Molecular Biotechnology 57: 904-913.
Jutras PV, D’Aoust M-A, Couture M, Vezina L-P, Goulet M-C, Michaud D, Sainsbury F (2015) Modulating secretory pathway pH by proton channel co-expression can increase recombinant protein stability in plants. Biotechnology Journal 10: 1478-1486.
Sainsbury F, Lomonossoff GP (2014) Transient expressions of synthetic biology in plants. Current Opinion in Plant Biology 19: 1-7.
Sainsbury F, Zeng BJ, Middelberg APJ (2014) Towards designer nanoemulsions for precision delivery of therapeutics. Current Opinion in Chemical Engineering 4: 11-17.
Sainsbury F, Rhéaume A-J, Vorster BJ, Goulet M-C, Michaud D (2012) Discrimination of differentially inhibited cysteine proteases by activity-based profiling using cystatin variants with tailored specificities. Journal of Proteome Research 11: 5983-5993.
Sainsbury F, Saunders K, Aljabali AAA, Evans DJ, Lomonossoff GP (2011) Peptide-controlled access to the interior surface of empty virus nanoparticles. ChemBioChem 12: 2435-2440.
Sainsbury F, Cañizares MC, Lomonossoff GP (2010) Cowpea mosaic virus: the plant virus-based biotechnology workhorse. Annual Review of Phytopathology 48: 437-455.
PhD Chinese Academy of Sciences, ChinaARC DECRA Fellow and Associate Group Leader
ContactTelephone: +617 3346 4169; Email: firstname.lastname@example.org
Research: Rational Design and Synthesis of Multifunctional Nanostructures for Point-of-care Diagnosis with Electrochemistry and Surface-enhanced Raman ScatteringDr Yuling Wang is an Australian Research Council (ARC) DECRA Fellow (2014-2017). Since obtaining her PhD in 2009, she has been the recipient of three competitive national and international fellowships including prestigious Alexander von Humboldt (AvH) fellowship in 2010 and German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) individual grant in 2012. Since 2013, she has been working in Prof. Trau’s group on developing biosensors for point-of-care diagnosis, and continues publishing in leading journals, such as ACS Nano, Anal. Chem. Chem.Comm. etc. Her current research topics are design and synthesis of multifunctional nanostructures (fluorescent clusters and plasmonic nanoparticles) for sensitive biomarker detection by employing an innovative analytical/sensor platform with electrochemistry and surface-enhanced Raman scattering (SERS) as read-out technology.
Key PublicationsWang, Y.; Vaidyanathan, R.; Muhammad J. A. S.; Trau, M. Enabling Rapid and Specific Surface Enhanced Raman Scattering Immunoassay Using Nano-Scaled Surface Shear Forces. ACS Nano, 2015, 6, 6354–6362.Ng, B. Y. C; Xiao, W; West, N; Wee, E. J. H; Wang, Y; Trau, M. Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Anal. Chem., 2015, 87, 20, 10613-10618.Wang, Y.; Wee, Eugene J.H.; Trau, M. Highly sensitive DNA methylation analysis at CpG resolution by surface-enhanced Raman scattering via ligase chain reaction. Chem. Commun., 2015, 51, 10953-10956.Wang, Y.; Rauf, S.; Grewal, Y. S.; Spadafora, L. J.; Shiddiky, M. J.; Cangelosi, G.; Schlücker, S.; Trau, M. Duplex Microfluidic SERS Detection of Pathogen Antigens with Nanoyeast Single-Chain Variable Fragments. Anal. Chem., 2014, 86, 9930-9938Wang, Y; Chen, J; Irudayaraj, J, Nuclear Targeting Dynamics of Gold Nanoclusters for Enhanced Therapy of HER2(+) Breast Cancer; ACS Nano, 2011, 5, 9718-9725.Wang, Y; Seebald, J. L.; Szeto, D. P.; Irudayaraj, J. Biocompatibility and Biodistribution of Surface-Enhanced Raman Scattering Nanoprobes in Zebrafish Embryos: In vivo and Multiplex Imaging, ACS Nano, 2010, 4, 4039-4053.
PhD, Zhejiang University, China
ARC Future Fellow and Associate Group Leader
Telephone: +61 7 3346 4263, Email: email@example.com
Research: Biosurfactant, drug delivery, bio-inspired nanomaterials, vaccine delivery, microfluidics, controlled release
Dr Chun-Xia Zhao joined Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland in early 2008 as a Postdoctoral Fellow in Prof. Anton Middelberg's group, after obtained her PhD degree in Zhejiang University. In 2011, Dr Zhao was awarded an ARC Discovery project along with the Australian Postdoctoral Fellow as the sole investigator.
In 2014, she was awarded the prestigious ARC Future Fellow and appointed as the Associate Group Leader. Her research in bio-inspired nanotechnology and microfluidics has attracted more than $2M in research funding since 2011, including four Australian Research Council projects (ARC Future Fellowship project, two ARC discovery projects and one ARC Linkage project) as the lead investigator, two national prestigious fellowships (Australian Postdoctoral Fellowship and Australian Research Council Future Fellowship), UQ Early Career Award and UQ New Staff Start-Up grant. She has been invited to visit Harvard University as a Fellow of the School of Engineering and Applied Science (Oct - Dec, 2014) working with a leading pioneer in microcapillary and microfluidics ― Prof. David Weitz.
Dr Zhao has contributed substantial high quality scientific papers in international top refereed journals such as Angewandte Chemie International Edition, Chemical Communications, Journal of Materials Chemistry, AIChE Journal, Biotechnology and Bioengineering, Vaccine, and so on. Dr Zhao has been focusing on innovative research, and have been active in patent application to transfer her research into practical applications, as evidenced by her four patents.
Dr Zhao has established a recognised international presence in the fields of nanomaterials, microfluidics and drug delivery. She has been invited to submit Book chapters, reviews and research papers in leading journals, such as Advanced Drug Delivery Reviews (2013 Impact Factor 12.7), Chemical Engineering Science Special Issue on Microfluidic Engineering, Industrial Engineering & Chemical Research, Vaccines. She has also been invited to present her work at international conferences (World Congress of Chemical Engineering, Annual World Congress of Advanced Materials, Annual World Congress of NanoMedicine, Bionano Innovation Conference, etc). Dr Zhao is also an invited reviewer for more than 20 journals, including Advanced Materials, Chemical Communication, Lab on a Chip, Chemical Engineering Science, AIChE Journal, Langmuir, Journal of Chromatography A, Inorganic Chemistry, Journal of Chemical & Engineering Data, etc.
- 2014-2018: Australian Research Council (ARC) Future Fellowship. Platform technologies for multifunctional nanocarrier systems.
- 2015-2018: ARC Discovery Project. Next generation core-shell materials based on biomolecular dual-templating.
- 2014-2017: Prof. Anton Middelberg, Prof. Nikolai Petrovsky. ARC Linkage Project. Engineering improved technology for nanoparticle-based adjuvant manufacture.
- 2011-2014: ARC Discovery Project (along with the awarding of APD). Engineered nanoporous materials and composites having hierarchical structures by emulsion templating.
- 2012: UQ Early Career Research Grants. pH-responsive core-shell mesoporous silica nanocomposites for bioimaging and targeted drug delivery.
- 2011: UQ New Staff Research Start-up Fund. Biomimetic synthesis of inorganic nanoparticles using microfluidic crystals.
Top 20 Key Publications
Chun-Xia Zhao, Anton P.J. Middelberg. Chapter 10 "Stimuli-responsive peptide nanostructures at the fluid-fluid interface" in “Protein Nanotechnology: Protocols, Instrumentation, and Applications”, Second Edition, Juliet A. Gerrard (Editor); Springer Science+Business Media, 2013, DOI 10.1007/978-1-62703-354-1_10. Invited chapter
Chun-Xia Zhao, Mirjana Dimitrijev Dwyer, Alice Lei Yu, Yang Wu, Sheng Fang, Anton P. J. Middelberg*. A simple and low-cost platform technology for producing pexiganan antimicrobial peptide in E. coli. Biotechnology and Bioengineering. 2014 Nov 25. doi: 10.1002/bit.25505
David Wibowo, Chun-Xia Zhao, Anton Middelberg. Emulsion-templated silica nanocapsules formed using bio-inspired silicification. Chemical Communication, 2014, 50: 11325.
Chun-Xia Zhao* (Corresponding author), Anton P.J. Middelberg. Titania microparticles uisng a facile microfluidic mass-transfer control method. Chemical Engineering Science, 2014, 112: 10-14.
Liang Zhao, Arjun Seth, Nani Wibowo, Chun-Xia Zhao, Neena Mitter, Chengzhong Yu, Anton P.J. Middelberg. Nanoparticle vaccines. Vaccine, 2014, 32 3: 327-337. (Invited review article).
Chun-Xia Zhao* (Corresponding author). Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. Advanced Drug Delivery Reviews. 2013, 65: 1420-1446. (Invited paper). (Impact Factor: 12.89)
Chun-Xia Zhao, Anton P.J. Middelberg. Microfluidic mass-transfer control for the simple formation of complex multiple emulsions. Angewandte Chemie International Edition, 2009, 48: 1-5. (Impact Factor: 13.73)
Chun-Xia Zhao* (corresponding author), Lei Yu, Anton P.J. Middelberg. Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release. Journal of Materials Chemistry B. 2013, Journal of Materials Chemistry B. 2013, 1: 4828-4833. (Impact Factor: 6.10)
Chun-Xia Zhao* (corresponding author), Anton P.J. Middelberg. Microfluidic synthesis of monodisperse hierarchical silica particles with raspberry-like morphology. RSC Advances. 2013, 3 (44): 21227 – 21230. (Impact Factor:2.56)
Chun-Xia Zhao* (Corresponding author), Lizhong He, Shizhang Qi, Anton P.J. Middelberg. Nanoparticle synthesis in microreactors. Chemical Engineering Science, 2011, 66(7): 1463-1479. (Invited paper) (Impact Factor: 2.39). Top 10 hottest papers in 2011 and 2012.
Chun-Xia Zhao, Anton P.J. Middelberg. Two-phase microfluidic flows. Chemical Engineering Science, 2011, 66(7): 1394-1411. (Impact Factor: 2.39) Top 10 and 25 hottest papers in 2011 and 2012.
Chun-Xia Zhao* (corresponding author), Anton P.J. Middelberg. One-step fabrication of titania hollow spheres by controlled interfacial reaction in a droplet-based microfluidic system. Microfluidics and Nanofluidics. 2013, 14(3): 703-709. (Impact Factor: 3.22)
Chun-Xia Zhao, Elisabeth Rondeau, Justin J. Cooper-White, Anton P.J. Middelberg. Microfluidic elucidation of the effects of interfacial rheology on droplet deformation. Industrial & Engineering Chemistry Research, (Invited paper) 2012, 51, 2021-2029. (Impact Factor: 2.21)
Chun-Xia Zhao* (corresponding author), Lei Yu, Anton P.J. Middelberg. Design of Low-Charge Peptide Sequences for High-Yield Formation of Titania Nanoparticles. RSC Advances, 2012, 2: 1292-1295. (Impact Factor:2.56)
Chun-Xia Zhao, Erik Miller, Justin J. Cooper-White, Anton P.J. Middelberg. Effects of fluid-fluid interfacial elasticity on droplet formation in microfluidic devices. AIChE Journal, 2011, 57(7): 1669-1677. (Impact Factor: 2.49)
Chun-Xia Zhao, Chao-Hong He. Mass transfer and separation criteria for high-speed countercurrent chromatography. AIChE Journal, 2011, 57(2): 359-372. (Impact Factor: 2.49)
Chun-Xia Zhao, Ya-Lan Xu, Chao-Hong He. Axial dispersion in high-speed counter-current chromatography. Journal of Chromatography A, 2009, 1216: 4841-4846. (Impact Factor: 4.61)
Chun-Xia Zhao, Chao-Hong He. Sample capacity in preparative high-speed counter-current chromatography, Journal of chromatography A, 2007, 1146: 186-192. (Impact Factor: 4.61)
Chun-Xia Zhao, Chao-Hong He. Solubility of atractylenolide III in hexane, ethyl acetate, diethyl ether, and ethanol from (283.2 to 323.2) K. Journal of Chemical & Engineering Data, 2007, 52: 1223-1225. (Impact Factor: 2.00)
Einar O. Fridjonsson, Thusara C. Chandrasekera, Andrew J. Sederman, Michael L. Johns, Chun-Xia Zhao, Anton P.J. Middelberg. Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette Shear Cell. Soft Matter, 2011, 7, 2961-2967. (Impact Factor: 3.91)
Dr Zhao's research expertise is nanomaterials for drug delivery and controlled release, microfluidics for making sophisticated materials and screening drug delivery systems, and biomolecular engineering for sustainable materials, including a number of directions:
- Emulsion and biomimetic dual-templating technology for making silica capsules for controlled and sustained release;
- Stimuli-responsive soft materials based on biomolecules manufactured from renewable resources.
- Simple and low-cost platform technology for producing bioproducts, including peptide or protein biosurfactants, peptide antibiotics.
- Microfluidic synthesis of hierarchical materials for applications in sustained and controlled drug release.
- Microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties.
- In vivo-mimicking Tissue Chips for screening and evaluating nanocarriers.