Professor Matt Trau and, below, videos relevant to his research. The first video is Prof Matt Trau in conversation with Dr Leroy Hood & Ravinder Sajwan recorded at the Consilium 2015 Conference (Sanctuary Cove, Aug 2015) as part of a session entitled “The new Science of Ageing and Wellness”. The second was recorded by the National Breast Cancer Foundation.
Professor Matt Trau and, below, videos relevant to his research. The first video is Prof Matt Trau in conversation with Dr Leroy Hood & Ravinder Sajwan recorded at the Consilium 2015 Conference (Sanctuary Cove, Aug 2015) as part of a session entitled “The new Science of Ageing and Wellness”. The second was recorded by the National Breast Cancer Foundation.

BSc (Hons) Syd, PhD (Physical Chemistry) Melb
AIBN Deputy Director and Group Leader

Centre for Personalised NanoMedicine

The Trau Laboratory website


Telephone: +61 7 334 64173 Email:

Research: Nanoscience, Nanotechnology, Molecular diagnostics

Professor Matt Trau is currently a Professor of Chemistry at The University of Queensland; and is also Deputy Director and co-founder of the Australian Institute for Bioengineering and Nanotechnology. Since graduating from the University of Sydney (BSc Hons I, University Medal) and the University of Melbourne (PhD in Physical Chemistry, 1993), he has held positions in industry and academia across the globe. These include a Fulbright Research Fellowship at Princeton University, USA; and a research
scientist at Dow Chemical and ICI Pty Ltd. Professor Trau has been a Visiting Professor at two of the largest Cancer Research Centres in the world: The Dana Farber Cancer Research Institute, Harvard Medical School, Boston (2000); and the Fred Hutchinson Cancer Research Centre, Seattle (2008). Professor Trau is internationally recognised for his innovative and cross-disciplinary research at the interface between chemistry, nanotechnology, biology and medicine. He has co-authored more than 120 refereed publications, many of which appear in the highest impact journals in his field, e.g., two Nature and two Science publications. His major awards and honours include an ARC Federation Fellowship (one of the most prestigious scientific fellowships in Australia), a Fulbright Research Fellowship to the USA; a Queensland Young Tall Poppy Award; a UQ Foundation/Vice Chancellor’s Research Excellence Award; a Paul Harris Fellowship; and a Pink Circle Award for breast cancer research excellence.

Leadership of major multi-disciplinary international programs

Professor Trau has raised more than $22 million in competitive national and international grant funding in the past 10 years. In the last five years, Professor Trau has initiated and led
several large international programs that involve close collaboration between leading nanotechnologists, molecular biologists, geneticists and commercial researchers - with the
goal of creating cutting edge diagnostics. These include a $4 million National and International Research Alliances Program (NIRAP) grant from the Queensland government ("International Partnership for preventative and Personalised Medicine)"; and two consecutive $5 million multidisciplinary collaborative grants from the National Breast Cancer Foundation (NBCF):
"Novel strategies for Prediction and Control of Advanced Breast Cancer via Nanoscaled Epigenetic-Based Biosensors", 2008-2013; and "Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalized Breast Cancer Care", 2013-2018. These grants involve research collaborations with some of the highest calibre scientists in the world, e.g., Dr Lee Hartwell (2001 Nobel Laureate) from Seattle was a co-chief investigator on the NIRAP grant, and each of the NBCF grants include leading geneticists, pathologists and oncologists from across Australia and around the world. In the past five years, he has been a consultant for a range of national and international companies such as Merck, Digene, Beckman Coulter, Panbio and A.I. Scientific, as well as being the founder and Director of Nanomics BioSystems Pty Ltd (a spinoff company from his laboratory).

Major plenary lectures and international conferences

Since 2003, Professor Trau has presented more than 60 invited plenary/keynote lectures at major international conferences spanning the disciplines of Chemistry, Nanotechnology, Chemical Engineering, Cancer and Diagnostics. Recent examples include: the 4th International NanoBio Conference, (Seattle) 2012; the 14th International Colloid & Surface Science Conference, (Japan) 2012; "Cancer Nanotechnology" Gordon Research Conference, (USA) 2011; the WA Cancer Conference 2011; Sydney Cancer Conference, 2010. In the past 10 years, Professor Trau has played the role of conference convenor, chair, co-chair and symposium chair for 10 major international conferences. Recent examples include: immediate past chair of the 1st International Conference on BioNano Innovation, (Brisbane) 2012; co-chair of the 5th International NanoBio Conference scheduled for Brisbane in 2014. 

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Recent Media

"Single Drop Genomics" UQ media release. March 2015

Recent Publications

Reviews & Commentaries

Wee, E. J. H.; Trau, M., Enzyme catalysis: Evolution made easy, Nature Chemistry, 6, 756-757, 2014.

Refereed Journal Articles 

Wong, N.C.L; Pope, B.J; Candiloro, I; Korbie, D; Trau, M; Wong, S.Q; Mikeska, T; van Denderen, B.J; Thompson, E.W; Eggers, S; Doyle, S; Dobrovic, A. Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat. GigaScience, 2015, Accepted November 2015.

Vaidyanathan, R; Dey, S; Carrascosa, L. G.; Shiddiky, M. J. A.; Trau, M. AC Electrohydrodynamics at the Nanoscale: Pushing Biomolecules and Cells around on Surfaces. Biomicrofluidics, 2015, Accepted November 2015. 

Vaidyanathan, R; Rauf, S; Grewal, Y; Spadafora, L; Shiddiky, M. J. A; Cangelosi, G; Trau, M. Enhancing Protein Capture Using a Combination of Nanoyeast Single-Chain Fragment Affinity Reagents and Alternating Current Electrohydrodynamic Forces. Anal. Chem., 2015, Accepted November 2015.

Ng, B. Y. C; Wee, E. J. H.; West, N. P.; Trau, M. Rapid DNA detection of Mycobacterium tuberculosis - towards single cell sensitivity in point-of-care diagnosis. Sci. Rep., 2015, 5, 15027. doi:10.1038/srep15027.

Wee, E. J. H.; Ngo, T. H.; Trau, M. A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation. Sci. Rep., 2015, 5, 15028.

Ng, B. Y. C; Xiao, W; West, N; Wee, E. J. H; Wang, Y; Trau, M. Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Anal. Chem., 2015, 87, 20, 10613-10618

Stone, A.; Zotenko, E.; Locke, W.; Korbie, D.; Millar, E.; Pidsley, R.; Stirzaker, C.; Graham, P.; Trau, M.; Musgrove, E.; Nicholson, R.; Gee' J.; Clark, S. DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer. Nat. Commun., 2015, 6, 7758.

Wee, E. J. H.; Ngo, T. H.; Trau, M. Colorimetric detection of both total genomic and loci-specific DNA methylation from limited DNA inputs. Clin. Epigenet., 2015, 7, 1, 1-9.

Koo, K. M.; Sina, A. A. I.; Carrascosa, L. G.; Shiddiky, M. J. A.; Trau, M. DNA-Bare Gold Affinity Interactions: Mechanism and Applications in Biosensing. Anal. Methods, 2015, 7, 7042 - 7054.

Wang, Y.; Wee, Eugene J.H.; Trau, M. Highly sensitive DNA methylation analysis at CpG resolution by surface-enhanced Raman scattering via ligase chain reaction. Chem. Commun., 2015, 51, 10953 - 10956.

Wang, Y.; Vaidyanathan, R.; Muhammad J. A. S.; Trau, M. Enabling Rapid and Specific Surface Enhanced Raman Scattering Immunoassay Using Nano-Scaled Surface Shear Forces. ACS Nano, 2015, 9, 6, 6354–6362.

Grewal, Y. S., Shiddiky, M. J. A., Spadafora, L. J., Cangelosi, G. A. & Trau, M. Structural Characterization of Nanoyeast Single-Chain Fragment Variable Affinity Reagents. J. Phys. Chem. C, 2015. 119, 22, 12674-12680.

Vaidyanathan, Ramanathan, van Leeuwen, Lara Michelle, Rauf, Sakandar, Shiddiky, Muhammad J. A. and Trau, Matt. A multiplexed device based on tunable nanoshearing for specific detection of multiple protein biomarkers in serum. Scientific Reports, 2015 5 9756. 

Wee, Eugene JH, Sakandar Rauf, Muhammad JA Shiddiky, Alexander Dobrovic, and Matt Trau. DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing. Clinical chemistry, 2015, 61, 1, 163-171. 

Korbie, Darren, Lin, Erica, Wall, David, Nair, Shalima S., Stirzaker, Clare, Clark, Sue J. and Trau, Matt. Multiplex bisulfite PCR resequencing of clinical FFPE DNA. Clin. Epigenet., 2015, 7, 28, 1-11.

O'Leary, V. B.; Ovsepian, S. V.; Carrascosa, L. G.; Buske, F. A.; Radulovic, V.; Niyazi, M.; Moertl, S.; Trau , M.; Anastasov, N.; Atkinson M. J.  PARTICLE – a triplex-forming long noncoding RNA amends locus specific methylation in response to low dose irradiation. Cell Rep., 2015, 11, 3, 474-485. 

Wee, E. J. H., Lau, H. Y., Botella, J. R. and Trau, M. Re-purposing bridging flocculation for onsite, rapid, qualitative DNA detection in resource-poor settings, Chem. Commun. 2015, 51, 5828-5831. (Front Cover)

Stirzaker, C., Zotenko, E., Song, J., Qu, W., Nair, S., Locke, W., Stone, A., Armstong, N., Robinson, M., Dobrovic, A., Avery-Kiejda, K., Peters, K., French, J., Stein, S., Korbie, D., Trau, M., Forbes, J., Scott, R., Brown, M., Francis, G., Clark, S. Methylome sequencing in triple negative breast cancer reveals distinct methylation clusters with prognostic value, Nature Communications, 2015, Feb 2. doi: 10.1038/ncomms6899. 

Lane, R., Korbie, D., Anderson,W., Vaidyanathan, R. and Trau, M. Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing, Scientific Reports, 2015. 5, 7639.1-7639.7.

Wee, E. J. H.; Trau, M., Measuring whole genome methylation via oxygen channelling chemistry, Chemical Communications, 50, 74, 10894-10896, 2014.

Wee, E. J. H.; Rauf, S.; Shiddiky, M. J.; Dobrovic, A.; Trau, M., DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing, Clinical Chemistry, 61, 1, 2014.

Wang, Y.; Rauf, S.; Grewal, Y. S.; Spadafora, L. J.; Shiddiky, M. J.; Cangelosi, G.; Schlücker, S.; Trau, M., Duplex microfluidic SERS detection of pathogen antigens with nanoyeast single-chain variable fragments, Analytical Chemistry, 86, 19, 9930-9938, 2014

Vaidyanathan, R.; Shiddiky, M. J. A.; Rauf, S.; Dray, E.; Tay, Z.; Trau, M., Tunable “nano-shearing”: A physical mechanism to displace nonspecific cell adhesion during rare cell detection, Analytical Chemistry, 86, 4, 2042-2049, 2014.

Vaidyanathan, R.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Tuneable surface shear forces to physically displace nonspecific molecules in protein biomarker detection, Biosensors and Bioelectronics, 61, 184-191, 2014.

Vaidyanathan, R.; Rauf, S.; Dray, E.; Shiddiky, M. J. A.; Trau, M., Alternating current electrohydrodynamics induced nanoshearing and fluid micromixing for specific capture of cancer cells, Chemistry – A European Journal, 20, 13, 3724-3729, 2014.

Sina, A. A. I.; Howell, S.; Carrascosa, L. G.; Rauf, S.; Shiddiky, M. J.; Trau, M., eMethylsorb: electrochemical quantification of DNA methylation at CpG resolution using DNA–gold affinity interactions, Chemical Communications, 50, 13153-13156, 2014.

Sina, A. A. I.; Carrascosa, L. G.; Palanisamy, R.; Rauf, S.; Shiddiky, M. J.; Trau, M., Methylsorb: A simple method for quantifying DNA methylation using DNA-gold affinity interactions, Analytical Chemistry, 86, 20, 10179-10185, 2014.

Shiddiky, M. J. A.; Vaidyanathan, R.; Rauf, S.; Tay, Z.; Trau, M., Molecular nanoshearing: An innovative approach to shear off molecules with AC-induced nanoscopic fluid flow, Scientific Reports, 4, 3716, 2014

Shah, A. M.; Hill, M. M.; Shiddiky, M. J.; Trau, M., Electrochemical detection of glycan and protein epitopes of glycoprotein in serum, Analyst, 139, 22, 5970-5976, 2014.

Rauf, S.; Shiddiky, M. J. A.; Trau, M., Electrohydrodynamic removal of non-specific colloidal adsorption at electrode interfaces, Chemical Communications, 50, 37, 4813-4815, 2014.

Lau, H. Y.; Palanisamy, R.; Trau, M.; Botella, J. R., Molecular inversion probe: A new tool for highly specific detection of plant pathogens, PLOS ONE, 9, 10, e111182, 2014.

Koo, K. M.; Wee, E. J. H.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Microdevices for detecting locus-specific DNA methylation at CpG resolution, Biosensors and Bioelectronics, 56, 278-285, 2014.

Koo, K. M.; Sina, A. A. I.; Carrascosa, L. G.; Shiddiky, M. J.; Trau, M., eMethylsorb: Rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes, Analyst, 139, 23, 6178-6184, 2014

Grewal, Y. S.; Shiddiky, M. J. A.; Spadafora, L. J.; Cangelosi, G. A.; Trau, M., Nano-yeast–scFv probes on screen-printed gold electrodes for detection of Entamoeba histolytica antigens in a biological matrix, Biosensors and Bioelectronics, 55, 417-422, 2014.

Carrascosa, L. G.; Sina, A. A. I.; Palanisamy, R.; Sepulveda, B.; Otte, M. A.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation, Chemical Communications, 50, 27, 3585-3588, 2014

New book published by the Trau lab in 2013

Shiddiky MJA, Wee EJH, Rauf S, Trau M (Eds). (2013) Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications. New York, US. Nova Biomedical.

Available in electronic and hardcopy from Nova Publishers, New York. Click here to view.

Student Opportunities

The Trau laboratory is interested in recruiting enthusiastic, high calibre students.

Apply for an Honours project with us.

Apply for a PhD or MPhil project with us.



Professor Matt Trau section

Trau Group media release archive

Releases from 2005-2015

Trau Group: Current Research Projects

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