• Professor Peter Gray

    Contact

    Telephone: +61 7 334 63899 Email: aibn.director@uq.edu.au

    Summary

    BSc Chem Eng (Hons) Syd, PhD NSW, FTSE, FIEAust, FAICD.
    AIBN Director and Group Leader

    Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.

    Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.

    Professor Gray serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.

    Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).

    Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses . He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.

    Key publications in the past five years

    Codamo J, Munro TP, Hughes BS, Song M, Gray PP. (2011) Enhanced CHO cell based transient gene expression with the Epi-CHO expression system. Molecular Biotechnology 48(2), 109-115.

    Prowse ABJ, Chong F, Gray PP, Munro TP. (2011) Stem cell integrins: Implications for ex-vivo culture and cellular therapies. Stem Cell Research 6(1), 1-12.

    Prowse ABJ, Doran MR, Cooper-White JJ, Chong F, Munro TR, Fitzpatrick J, Chung TL, Haylock DN, Gray PP, Wolvetang EJ. (2010) Long-term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials 31(32), 8281-8288.

    Ladewig K, Niebert M, Xu ZP, Gray PP, Lu GQ. (2009): Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles. Biomaterials 31(7), 1821-1829.

    Pilbrough W, Munro TP, Gray PP. (2009) Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS ONE 4(12), e8432. doi:10.1371/journal.pone.0008432.

  • Professor Debra Bernhardt

    Contact

    Telephone: +61 7 334 63939 Email: d.bernhardt@uq.edu.au

    Research: Theoretical and computational molecular science: nonequilibrium systems, fluids and materials

    Professor Debra Bernhardt is internationally recognised for her contributions to the development of nonequilibrium statistical mechanics and thermodynamics including far-from-equilibrium fluids and confined fluids. She is a Fellow of the Royal Australian Chemical Institute and Director of the AIBN Centre for Theoretical and Computational Molecular Science. Professor Bernhardt’s 20 years of research experience includes appointments at the University of Basel, Switzerland; the Australian National University; and Griffith University, where she was founding director of the Queensland Micro- and Nanotechnology Centre. Professor Bernhardt's research interests focus on the use of a range of theoretical and computational approaches to develop a fundamental understanding of the behaviour of matter, and application of these approaches to a wide range of problems including transport in nanopores, fluctuation phenomena, design of materials, gas separation, energy storage and conversion.

    International links

    Professor Bernhardt has held a research appointment at the University of Basel in Switzerland. She has recently had strong international collaborations with researchers at Politecnico di Torino, Italy; The University of Sheffield, UK; University of Leipzig, Germany; and École Normale Supérieure, France.

    Memberships and funding

    Professor Bernhardt is a Fellow of the Royal Australian Chemical Institute. She has has three current Australian Research Council (ARC) funding grants and has received ARC grant funding of more than $6.5 million since 1998. She has been involved in organisation of a number of conferences including Nonequilibrium Processes: the Last 40 years and the Future in Obergurgl, Austria in 2011; 1st Australian-Italian Workshop on Statistical Physics on the Gold Coast in 2006; and International Union of Pure and Applied Chemistry’s World Chemistry Congress 2001. She is co-chair of Molecular Modelling 2014, which will be held in Queensland.

    Awards and plenaries

    Professor Bernhardt has been plenary, keynote or invited speaker at many international conferences including the Joint European Thermodynamics Conference, (Brescia, Italy, 2013) Workshop on Small System Nonequilibrium Fluctuations (ICITP, Beijing, 2013); Fluid-Structure Interactions in Soft-Matter Systems: From the Mesoscale to the Macroscale (Prato, Italy, 2012); Gordon conference on the Chemistry and Physics of Liquids (New Hampshire, US, 2011); StatPhys-Kolkata VII (SINP, Kolkata, India, 2010); and the Warwick EPSRC Symposium on Challenges in Scientific Computing (University of Warwick, UK, 2009). In 2011, while at Griffith University, Professor Bernhardt was awarded the Vice Chancellor’s Research Excellence Award for Research Leadership. She is the recipient of the 2004 Australian Journal of Chemistry Award for Innovative Work in Physical Chemistry by a Younger Scientist.

    Recent Publications

    Professor Bernhardt publishes using her maiden name, Debra J Searles. For a full publication list click here

    Liao, Ting, Sun, Ziqi, Sun, Chenghua, Dou, Shi Xue and Searles, Debra J. (2014) Electronic coupling and catalytic effect on H2 evolution of MoS2 /graphene nanocatalyst. Scientific Reports, 4 6256.1-6256.7.  PDF

    Davie, Stuart J, Jepps, Owen G, Rondoni, Lamberto, Reid, James C and Searles, Debra J (2014) Applicability of optimal protocols and the Jarzynski equality. Physica Scripta, 89 4:.  PDF


    Williams, Stephen R., Searles, Debra J. and Evans, Denis J. (2014) On the relationship between dissipation and the rate of spontaneous entropy production from linear irreversible thermodynamics. Molecular Simulation, 40 1-3: 208-217. PDF


    Sun, Chenghua and Searles, Debra J. (2013) Origin of the visible light absorption of boron/nitrogen Co-doped anatase TiO2. Journal of Physical Chemistry C, 117 50: 26454-26459. PDF


    Michel, Guillaume and Searles, Debra J. (2013) Local fluctuation theorem for large systems. Physical Review Letters, 110 26:. PDF


    Sun, Qiao, Li, Zhen, Searles, Debra J., Chen, Ying, Lu, Gaoqing (Max) and Du, Aijun (2013) Charge-controlled switchable CO2 capture on boron nitride nanomaterials. Journal of the American Chemical Society, 135 22:  8246-8253. PDF


    Searles, Debra J., Johnston, Barbara M., Evans, Denis J. and Rondoni, Lamberto (2013) Time reversibility, correlation decay and the steady state fluctuation relation for dissipation. Entropy, 15 5: 1503-1515. PDF


    Davie, Stuart J., Reid, James C. and Searles, Debra J. (2013) Free energy calculations with reduced potential cutoff radii. Journal of Chemical Theory and Computation, 9 4: 2083-2089. PDF

  • Professor Justin Cooper-White, above, and his research on meniscus regeneration explained, below.
    BE (Chem) (Hons) UQ, PhD UQ
    Group Leader

    Contact

    Telephone: +61 7 334 63858 Email: j.cooperwhite@uq.edu.au

    Research: Smart surfaces, scaffolds and diagnostic microdevices for stem cell expansion, tissue engineering and early disease detection

    Professor Justin Cooper-White is a global leader in using engineering to solve problems in biology. In addition to holding the position of AIBN Group Leader, Professor Cooper-White is Director of the Australian National Fabrication Facility-Queensland Node and the Associate Dean (Research) Faculty of Engineering, Architecture and Information Technology at UQ. He is a past President of both the Australasian Society for Biomaterials and Tissue Engineering and the Australian Society of Rheology.

    International links

    Professor Cooper-White has many past and currently active international collaborations with world leading research groups at MIT (US); Stanford (USA); ETH (Switzerland); EPFL (Switzerland); SNU (Korea); University Of Grenoble (France); Politecnico di Milano (Italy); UCL (UK); and the Max Planck Institute (Germany). He has performed contract research and consultancy work for Unilever in the UK; Nestle International, Switzerland; Rhodia, US; and Inion, Finland since 2001. He has previously held a Visiting Professor Fellowship (2007) at ETH Zurich and currently holds a Politecnico di Milano Visiting Professor Fellowship for 2012-2013. He is the associate editor of the Korean-Australian Rheology Journal; serves or has served on the editorial boards of Rheological Acta, Soft Materials, Biomicrofluidics and the Open Biomedical Engineering Journal; and is a reviewer of major international journals, including Nature Methods, Advanced Materials, Lab on a Chip, Stem Cells, Stem Cells and Development, Biomacromolecules, Tissue Engineering, Langmuir, Biomaterials and Journal of Non-Newtonian Fluid Mechanics.

    Memberships, patents and funding

    Professor Cooper-White has been chair or co-chair of three international conferences, focusing on either rheology or biomaterials and tissue engineering: the Australian representative on the International Advisory Committee, 15th International Congress on Rheology, Monterey, US; a member of the International Scientific Advisory Committee for the World Congress on Biomaterials, Amsterdam, Netherlands; and currently an Australian representative on the Interntional Union of Societies for Biomaterials Science and Engineering (IUSBE). He is the inventor on six international patents. He has performed contract and sponsored research work for multinationals such as Mesoblast, Rhodia, Unilever and Nestle International and has received more than $45 million in competitive grant funding.

    Awards and plenaries

    Recognition of Professor Cooper-White’s standing in the research field is reflected in the nine plenary and more than 25 keynote presentations he has been invited to give at national and international conferences since 2001. He received the 2005 Annual Award of the British Society of Rheology for contributions to the fields of rheology and non-Newtonian fluid mechanics. His work on engineered surfaces, specifically for directing mesenchymal stem cell fate was highlighted as one the most influential works on stem cell – biomaterial interactions at the 2008 World Biomaterials Congress in Amsterdam, the Netherlands.

    Key publications in the past five years

    Frith JE, Mills RJ, Cooper-White JJ. (2012) Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour. Journal of Cell Science 1252), 317-327.

    Titmarsh DM, Hudson JE, Hidalgo A, Elefanty AG, Stanley EG, Wolvetang EJ, Cooper-White JJ. (2012) Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One 7(12). e52405.

    Tan GK, Dinnes DLM, Butler LN, Cooper-White JJ. (2010) Interactions between meniscal cells and a self assembled biomimetic surface composed of hyaluronic acid, chitosan and meniscal extracellular matrix molecules. Biomaterials 31(23), 6104-6118.

    Cameron AR, Frith JE, Cooper-White JJ. (2011) The influence of substrate creep on mesenchymal stem cell behaviour and phenotype. Biomaterials 32(26), 5979-5993.

    Hudson JE, Brooke G, Blair C, Wolvetang EJ, Cooper-White JJ. (2011) Development of myocardial constructs using modulus-matched acrylated polypropylene glycol triol substrate and different nonmyocyte cell populations. Tissue Engineering - Part A 17(17-18), 2279-2289.

    Doran MR, Mills RJ, Parker AJ, Landman KA, Cooper-White JJ. (2009) A cell migration device that maintains a defined surface with no cellular damage during wound edge generation. Lab Chip 9(16), 2364-2369.

    Rowlands AS, George PA, Cooper-White JJ. (2008) Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation. American Journal of Physiology Cell Physiology 295(4), C1037-1044.

    Chau L, Doran M, Cooper-White JJ. (2009) A novel multishear microdevice for studying cell mechanics. Lab Chip 9(13), 1897-1902.

    George PA, Donose BC, Cooper-White JJ. (2009) Self-assembling polystyrene-block-poly(ethylene oxide) copolymer surface coatings: Resistance to protein and cell adhesion. Biomaterials 30(13) 2449-2456.

  • Professor John Drennan

    BSc (Hons) Flinders, PhD Flinders
    Affiliate Group Leader

    Contact

    Telephone: +61 7 334 63966 Email: j.drennan@uq.edu.au

    Research: Materials development and characterisation

    Professor John Drennan is an internationally-recognised expert in advanced materials characterisation and has worked with the US Department of Energy; National Institute of Materials Science (NIMS), Japan; and IBM. Professor Drennan has held four Australian Research Council (ARC) Discovery grants. He has worked at Imperial College, London and been an external reviewer for the Australian Nuclear Science and Technology Organisation (ANSTO).

    International links

    Professor Drennan has been a post-doctoral researcher at Imperial College, London; worked for the CSIRO; and was seconded to Ceramic Fuel Cells, Melbourne. He has collaborated with Professor Richard Catlow from University College London; Professor Peter Battle from the University of Oxford; and the National Institute of Materials Science (NIMS) in Japan. NIMS appointed Professor Drennan an International Fellow – the only Australian to be granted the honour. He has been selected to review the US Department of Energy’s program Structural Ceramics and Mechanical Behaviour of Ceramics: Emphasis on Microstructure and Microchemistry.

    Memberships, patents and funding

    Professor Drennan has been a member of the International Advisory Committee of the NanoCluster at Nanyang Technological University, Singapore; an external reviewer of the materials division of the Australian Nuclear Science and Technology Organisation (ANSTO); and a reviewer for international journals such as the Journal of Materials Science, Solid State Ionics, the Journal of European Ceramics Society and the Journal of Japanese Ceramic Society. Professor Drennan has been a visiting scientist at IBM’s TJ Watson Research Centre in New York, US. He has been an associate editor of the Journal of the American Ceramic Society. Professor Drennan has been a key driver in obtaining more than $12 million in infrastructure funding from competitive sources, including the ARC and National Collaborative Research Infrastructure Strategy.

    Awards and plenaries

    Professor Drennan is the recipient of the 2010 John Sanders Medal from the Australian Microscopy and Microanalysis Society; two travelling fellowships from the Science and Techology (STA) Agency, Japan; and a Commonwealth Post Graduate Scholarship. He was the invited plenary lecturer at the International Symposium on EcTopia Science at Nagoya University, Japan, in December 2011.

    Key publications for the past five years

    Chauhan, Shipra, Richards, Gary J., Mori, Toshiyuki, Yan, Pengfei, Hill, Jonathan P., Ariga, Katsuhiko, Zou, Jin and Drennan, John (2013) Fabrication of a nano-structured Pt-loaded cerium oxide nanowire and its anode performance in the methanol electro-oxidation reaction. Journal of Materials Chemistry A, 1 20: 6262-6270. PDF

    Fugane, Keisuke, Mori, Toshiyuki, Ou, Ding Rong, Yan, Pengfei, Ye, Fei, Yoshikawa, Hideki and Drennan, John (2012) Improvement of cathode performance on Pt-CeOx by optimization of electrochemical pretreatment condition for PEFC application. Langmuir, 28 48: 16692-16700. PDF

    Han, Guang, Chen, Zhi-Gang, Zou, Yichao, Drennan, John and Zou, Jin (2014) Long wavelength emissions of Se4+-doped In2O 3 hierarchical nanostructures. Journal of Materials Chemistry C, 2 32: 6529-6535. PDF

    Han, Guang, Chen, Zhi-Gang, Drennan, John and Zou, Jin (2014) Indium selenides: structural characteristics, synthesis and their thermoelectric performances. Small, 10 14: 2747-2765. PDF

    Han, Guang, Chen, Zhi-Gang, Ye, Delai, Yang, Lei, Wang, Lianzhou, Drennan, John and Zou, Jin (2014) In-doped Bi2Se3 hierarchical nanostructures as anode materials for Li-ion batteries. Journal of Materials Chemistry A, 2 19: 7109-7116. PDF

    Han, Guang, Chen, Zhi-Gang, Yang, Lei, Cheng, Lina, Drennan, John and Zou, Jin (2013) Phase control and formation mechanism of new-phase layer-structured rhombohedral In3Se4 hierarchical nanostructures. Crystal Growth and Design, 13 11: 5092-5099. PDF

    Lashtabeg, Anna, Smart, Michael, Riley, Daniel, Gillen, Andrew and Drennan, John (2013) The effect of extreme temperature in an oxidising atmosphere on dense tantalum carbide (TaC). Journal of Materials Science, 48 1: 258-264.  PDF

    Li, Zhi-Peng, Mori, Toshiyuki, Auchterlonie, Graeme John, Zou, Jin and Drennan, John (2012) Incubational domain characterization in lightly doped ceria. Journal of Solid State Chemistry, 192 28-33. PDF

    Li, Zhi-Peng, Mori, Toshiyuki, Ye, Fei, Ou, Dingrong, Auchterlonie, Graeme John, Zou, Jin and Drennan, John (2012) Cerium-reduction-induced defects clustering, ordering, and associated microstructure evolution in yttrium-doped ceria. Journal of Physical Chemistry C, 116 9: 5435-5443.  PDF

    Li, Zhi-Peng, Mori, Toshiyuki, Auchterlonie, Graeme John, Zou, Jin and Drennan, John (2012) Nanodomain formation and distribution in Gd-doped ceria. Materials Research Bulletin, 47 3: 763-767.  PDF

    Li, Zhi-Peng, Mori, Toshiyuki, Zou, Jin and Drennan, John (2012) Optimization of ionic conductivity in solid electrolytes through dopant-dependent defect cluster analysis. Physical Chemistry Chemical Physics, 14 23: 8369-8375.  PDF

    Li, Zhi-Peng, Mori, Toshiyuki, Zou, Jin and Drennan, John (2013) Defects clustering and ordering in di- and trivalently doped ceria. Materials Research Bulletin, 48 2: 807-812.  PDF

    Mori, Toshiyuki, Ou, Ding Rong, Zou, Jin and Drennan, John (2012) Present status and future prospect of design of Pt-cerium oxide electrodes for fuel cell applications. Progress in Natural Science: Materials International, 22 6: 561-571.  PDF

    Wang, Ya, Liao, Zhiming, Xu, Hongyi, Xiu, Faxian, Kou, Xufeng, Wang, Yong, Wang, Kang L., Drennan, John and Zou, Jin (2011) Structural evolution of GeMn/Ge superlattices grown by molecular beam epitaxy under different growth conditions. Nanoscale Research Letters, 6 624.1-624.6.  PDF

    Yan, Pengfei, Mineshige, Atsushi, Mori, Toshiyuki, Wu, Yuanyuan, Auchterlonie, Graeme John, Zou, Jin and Drennan, John (2013) Microanalysis of a Grain Boundary's Blocking Effect in Lanthanum Silicate Electrolyte for Intermediate-Temperature Solid Oxide Fuel Cells. ACS Applied Materials and Interfaces, 5 11: 5307-5313.  PDF

    Yan, Pengfei, Mori, Toshiyuki, Wu, Yuanyuan, Li, Zhimin, Auchterlonie, Graeme John, Zou, Jin and Drennan, John (2013) Microstructural and chemical characterization of ordered structure in yttrium doped ceria. Microscopy and Microanalysis, 19 1: 102-110.   PDF

    Yan, P. F., Mori, T., Suzuki, A., Wu, Y. Y., Auchterlonie, G. J., Zou, J. and Drennan, J. (2012) Grain boundary's conductivity in heavily yttrium doped ceria. Solid State Ionics, 222-223 31-37.  PDF

    Zhao, Ling, Drennan, John, Kong, Chun, Amarasinghe, Sudath and Jiang, San Ping (2014) Insight into surface segregation and chromium deposition on La 0.6Sr0.4Co0.2Fe0.8O 3-δ cathodes of solid oxide fuel cells. Journal of Materials Chemistry A, 2 29: 11114-11123.  PDF

  • Professor Peter Halley

    BE (Chem) (Hons) UQ, PhD UQ, Grad. Cert. Higher Education UQ
    Group Leader

    Contact

    Telephone: +61 7 334 63881 Email: p.halley@uq.edu.au

    Research: Biofluids characterisation and biopolymer processing

    Professor Peter Halley is a leading international expert in bio-based polymers and translational polymer research. His initial work on Australia's first biodegradable thermoplastic starch polymers led to the establishment of spin-off company Plantic Technologies, more than $75 million in venture financing, sales of commercially-viable products and a continued research provider relationship with Plantic. Professor Halley has led translational research projects in biopolymers and biofluid platforms for agrifood, biomedical and high-value manufacturing sectors which have attracted more than $14 million in government and industry funding; and produced patents, licences and new industrial know-how. Professor Halley is a fellow of the Royal Australian Chemical Institute (RACI) and the Institution of Chemical Engineers (IChemE). He is on the editorial board of three journals.

    International links

    Professor Halley has been visiting or invited professor at Queen’s University Belfast, the University of Strasbourg and Institut national des sciences appliquées de Lyon in France. He also has strong international collaborations with Los Alamos National Labs, US; the Cadbury Research Centre, UK; the US Department of Agriculture; Colorado School of Mines, US, AnoxKaldnes, Sweden; University of Bradford, UK; the University of Warwick, UK; and TNO, the Netherlands.

    Memberships, patents and funding

    Professor Halley has led research projects in biopolymers and biofluid platforms which have attracted more than $14 million in continuous government and industry funding since 1995. He has a patent portfolio of including patents in starch polymers, lignin polymers and oxodegradable polymers. Professor Halley was made a Fellow of the Royal Australia Chemical Institute in 2008 and a Fellow of the Institution of Chemical Engineers in 2006.

    Awards and plenaries

    Professor Halley has a Queen’s University Belfast Visiting Professor Fellowship. He received an Invited Professorship at Institut national des sciences appliquées de Lyon in France and was awarded the Cooperative Research Centres (CRC) for Polymers Chairman’s Award for Excellence in Commercialisation. Innovation and technology transfer awards have been awarded by the CRC Association, CRC Sugar and CRC Food Packaging. Among more than 40 invited keynotes and plenaries were presentations at the International Biopolymer Symposium, Strasbourg, France; PPS international meeting, Banff, Canada; World Congress on Chemical Engineering, Montreal, Canada; and BioEnvironmental Polymer Society international meeting, Monterrey, Mexico.

    Key publications in the past five years

    Halley PJ and Avérous L., (2014) Starch polymers: from genetic engineering to green applications. Amsterdam, Netherlands: Elsevier, 2014.

    Laycock B, Halley PJ, Pratt S, Werker A, Lant P. (2012) The chemomechanical properties of microbial polyhydroxyalkanoates. Progress in Polymer Science, doi: 10.1016/j.progpolymsci.2012.06.003

    Xie F, Halley PJ, Avérous L. (2012) Rheology to understand and optimize processibility, structures and properties of starch polymeric materials. Progress in Polymer Science 37, 595-623

    Liu W-C, Halley PJ, Gilbert RG. (2010) Mechanism of Degradation of Starch, a Highly Branched Polymer, during Extrusion. Macromolecules 43(6), 2855–2864.

    Halley PJ, George G. (2009) Chemorheology of Polymers: from fundamental principles to reactive processing, Cambridge University Press, Cambridge.

  • Professor Mark Kendall, above, and his research explained in a TEDGlobal talk and a Rolex video, below (click to view) (photo courtesy of Rolex/Proudfoot).
    ARC Future Fellow and Group Leader
    BE (Hons I) UQ, PhD UQ

    Contact

    Telephone: +61 7 334 64203 Email: m.kendall@uq.edu.au

    Research: Targeting the skin for needle-free, minimally invasive vaccine delivery and diagnostics for disease

    Professor Mark Kendall is the inventor of the Nanopatch, a needle-free vaccine delivery device which is under rapid research and development to product through spin-out company Vaxxas. Professor Kendall is a 2012 Rolex Laureate, recognising pioneering efforts to expand knowledge and improve human life. He co-founded Vaxxas with $15million in capital investment - one of the largest investments in an Australian start-up
    biotechnology company. The Nanopatch technology has been licensed to US-based pharma-
    ceutical company Merck & Co. Professor Kendall’s research group received the Eureka Prize for Research by an Interdisciplinary Team in 2011. Professor Kendall is an inaugural Australian Research Council Future Fellow.

    International links

    Professor Kendall has key international links spanning academia and industry including the University of Oxford, where he was a lecturer; Harvard; PATH; WHO; and the University of Washington. Professor Kendall is a member of a Scientific Advisory Group sponsored by the WHO that aims to fast−track the development of needle−free vaccine delivery technology for use in poor countries. His Nanopatch technology has been licensed to US –based pharmaceutical company Merck & Co. Professor Kendall has lectured at the University of Oxford. While there, he was instrumental in building up PowderJect/PowderMed, which was sold to Pfizer for $US400
    million.

    Memberships, patents and funding

    Professor Kendall is the recipient of more than $40 million in competitive research funding and another $33 million from industry. He edits papers in the Journal of Nanotechnology and Shock Waves Journal. Professor Kendall is the inventor of 96 patents.

    Awards and plenaries

    Professor Kendall is a Rolex Laureate, recognising pioneering efforts to expand knowledge and improve human life. He is the recipient of many prestigious accolades, including The Australian Innovation Challenge in 2011. His AIBN group received the 2011 Eureka Prize for Interdisciplinary Research; and the Queensland Clinical Trial Network and Merck’s 2010 Translational Research Excellence Commercialisation Award. Professor Kendall won the Australian Society for Medical Research and Amgen’s Australia Medical Researcher Award in 2008; and was named Young Engineer of Britain 2004. He has presented at more than 90 international seminars and conferences, including the plenary at the 9th Symposium of the Lohmann Therapie-Systeme Academy (LTS) in Germany in 2012.

    Key publications in the past five years

    Yeow B, Coffey JW, Muller DA, Grøndahl L, Kendall MAF, Corrie SR. (2013) Surface modification and characterization of polycarbonate microdevices for capture of circulating biomarkers, both in vitro and in vivo. Analytical Chemistry 85(21), 10196-10204.
     
    Coffey JW, Corrie SR, Kendall MAF. (2013) Early circulating biomarker detection using a wearable microprojection array skin patch. Biomaterials 34(37), 9572-9583.
     
    Pearson F, McNeilly CL, Crichton ML, Primiero CA, Yukiko SR, Fernando GJP, Chen X, Gilbert SC, Hill AVS, Kendall MAF. (2013) Dry-coated live viral vector vaccines delivered by Nanopatch microprojectsion retain long-term thermostability and induce transgene-specific T cell responses in mice. PLoS One 8(7), e67888.
     
    Meliga SC, Flaim C, Veidt M, Kendall MAF. (2013) The mechanical stress caused by micro-projection arrays penetrating the skin for vaccine delivery. Australian Journal of Multi-Disciplinary Engineering 10(2), 173-184.
     
    Raphael AP, Meliga SC, Chen X, Fernando GJP, Flaim C, Kendall MAF. (2013) Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers. The Journal of Controlled Release 166(2), 87-94.
     
    Crichton ML, Chen X, Huang H, Kendall MAF. (2013) Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales. Biomaterials 34(8), 2087-2097.
     
    Fernando GJP, Chen X, Primero CA, Yukiko SR, Fairmaid EJ, Corbett HJ, Frazer IH, Brown LE, Kendall MAF. (2012) Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses. Journal of Controlled Release 159(2), 215-221.
     
    Crichton ML, Donose BC, Chen X, Raphael A, Huang H, Kendall MAF. (2011) The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers. Biomaterials 32(20), 4670-4681.
     
    Chen X, Fernando GJP, Crichton ML, Flaim C, Yukiko SR, Fairmaid EJ, Corbett HJ, Primiero CA, Ansaldo AB, Frazer IH, Brown LE, Kendall MAF. (2011) Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization. Journal of Controlled Release 152(3), 349-355.
     
    Corrie S, Fernando GJP, Crichton ML, Brunck MEG, Anderson CP, Kendall MAF. (2010) Surface-modified microprojection arrays for intradermal biomarker capture, with low non- specific protein binding. Lab on a Chip 10, 2655-2658.
     
    Fernando GJP, Chen X, Prow TW, Crichton ML, Fairmaid EJ, Roberts MS, Frazer IH, Brown LE, Kendall MAF. (2010) Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse Model. PLoS ONE 5(4), e10266. doi:10.1371/journal.pone.0010266.
     
  • Associate Professor Stephen Mahler

    BSc (Hons) Syd, PhD UQ
    Affiliate Group Leader

    Contact

    Telephone: +61 7 3365 4172 or +61 7 3346 3175 Email: s.mahler@eng.uq.edu.au

    Research: Research and development of biologic medicines

    Associate Professor Stephen Mahler has made significant contributions to biopharmaceutical discovery, development and delivery, including development of technology for producing human antibody biopharmaceuticals. Associate Professor Mahler has secured more than $2 million in Australian Research Council (ARC) funding during the past four years for projects principally associated with biologics discovery, recombinant protein production and development of targeted drug delivery systems.

    International links

    Associate Professor Mahler has delivered short courses in biologics nationally and internationally to big pharma, biotechnology companies, regulatory agencies and universities, including Pfizer Australia; the National Pharmaceutical Control Bureau, Malaysia; and at the National Forum for Biosimilars, Brazil. He has consulted for a wide range of biotechnology companies both nationally and internationally including Pfizer and Abbott. He also has academic collaborations with University of Cambridge United Kingdom and Nanyang Technological University, Singapore in the areas of Antibody Engineering and Targeted Drug Delivery, respectively.

    Memberships, patents and funding

    Associate Professor Mahler has been a member of the editorial board of the Journal of Chemical Technology and Biotechnology since 2004; and an OzReader for the Australian Research Council since 2003, reviewing ARC Discovery, Linkage, Australian Federation Fellowship, Australian Future Fellowships and ARC Centre applications. Prior to joining the AIBN, Associate Professor Mahler was co-director of the Bioengineering Centre at the University of NSW, and secured $2 million in National Collaborative Research Infrastructure Strategy (NCRIS) funding for establishing the Recombinant Products NCRIS node at UNSW. Since 2007, Associate Professor Mahler has been interacting with biotechnology companies and has secured research funding from industry sources. Two provisional patent applications are now in the process of being submitted.

    Awards and plenaries

    • Molecular medicine conference Asia, May 2013 (Click here for details)
    • Biopharma Asia Conference, March 2013 (Click here for details)

    Key publications for past five years

    Mahler SM. (2011) Biologics and biosimilars: emerging technologies driving global opportunity. J Chem Technol and Biotechnol 86(7), 893-894.

    Pile KD, Graham GG, Mahler SM, Day RO. (2011) Disease-modifying antirheumatic drugs. In Principles of immunopharmacology (third ed.). Nijkamp FP, Parnham MJ (Eds.), (pp. 585-619) Basel, Switzerland: Springer.

    Munro TP, Mahler SM, Huang EP, Chin DY, Gray PP. (2011) Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates. mAbs 3(5), 440-452.

    Falconer RJ, Jackson-Matthews D, Mahler SM. (2011) Analytical strategies for assessing comparability of biosimilars. J Chem Technol and Biotechnol 86(7), 915-922.

    Jones ML, Seldon T, Smede M, Linville A, Chin DY, Barnard R, Mahler SM, Munster D, Hart D, Gray PP, Munro TP. (2010) A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. Journal of Immunological Methods 354, 85-90.

    Matigian N, Abrahamsen G, Sutharsan R, Cook A, Nouwens A, Bellette B, Vitale A, An J, Anderson M, Beckhouse B, Cecil R, Chalk A. Cochrane J, Fan Y, Féron F, McCurdy R, McGrath J, Perry C, Raju J, Ravishankar S, Silburn P, Sutherland G, Mahler SM, Mellick G, Wood S, Sue C, Wells CA, Mackay-Sim A. (2010) Disease-specific, neurosphere-derived cells as models for brain disorders. Disease Models and Mechanisms 3, 785-798.

    Nouwens A, Mahler SM. (2012) Evolution of proteomic methods for analysis of complex biological samples - implications for personalized medicine. In Integrative Proteomics. Hon-Chiu Eastwood L, Tsz-Kwong M, Ricardo JF (Eds.), (pp. 29-43) Croatia: InTech.

  • Professor Darren Martin

    BApplSci (Materials) UTS, PhD UTS
    AIBN Deputy Director (Graduate Studies) and Group Leader

    Contact

    Telephone: +61 7 334 63870 Email: darren.martin@uq.edu.au

    Research: Polymer nanocomposites and nanotoxicology

    Professor Darren Martin is the Chief Scientific Officer for start-up company TenasiTech Pty Ltd, which is commercialising a polymer nanocomposites platform as applied to large polyurethane and acrylic polymer markets and applications. TenasiTech is the first Queensland start-up to receive Commercialisation Australia funding; has won the prestigious iLab Prize in the national Enterprize Competition; and received the 2010 UQ EAIT Commercialisation award. Professor Martin’s research operates at the nexus of three key themes; (1) Strong fundamental materials science with global benchmarking; (2) Safe biomaterials and nanomaterials; (3) Scalable advanced manufacturing. His efforts in these areas during the past two decades have contributed to two successful start-ups, numerous products and a strong platform for globally competitive nanocomposites innovation.

    International links

    Professor Martin’s international collaborators include Pennsylvania State University; Purdue University, US; Queen’s University Belfast, UK; Institut national des sciences appliquées de Lyon, France; and the University of Padova, Italy. He also has several materials co-development projects and collaborations with companies such as Cochlear Ltd, Aortech Biomaterials, the EGR Group and several others in North America, Europe and Asia.

    Memberships, patents and funding

    Professor Martin has been the recipient of three Australian Research Council (ARC) Discovery Grants and has secured more than $9 million in research and commercialisation funding since 1999. He has two granted patents and two provisional patents in these areas. He is working with Australian regulators such as NICNAS and WorkSafe Australia on policy for nanomaterials/nanocomposites safety and occupational hygiene. Professor Martin is a member of the Engineers Australia Nanoengineering panel and has presented more than 10 keynotes or invited lectures. During the past five years a large proportion of his research funding has been derived from the private sector.

    Key publications for the past five years

    Belcher C, Marshall R, Edwards G, Martin DJ. (2012) The Commercialization of Nanotechnology: The Five Critical Success Factors to a Nanotech-enabled Whole Product, in Nanotechnology Commercialization. Tsuzuki T (Ed.), Singapore: Pan Stanford Publishing. ISBN: 9789814303286.

    Butler MK, Prow TW, Guo Y-N, Lin LL, Webb RI, Martin DJ. (2012) High-pressure freezing/freeze substitution and transmission electron microscopy for characterization of metal oxide nanoparticles within sunscreens. Nanomedicine 7(4), 541-551. (Most direct quantitative approach for in-situ assessment of nanoscale metal oxide additives in sunscreen formulations).

    Musumeci A, Gosztola D, Schiller T, Dimitrijevic NM, Mujica V, Martin DJ. (2009) SERS of semiconducting nanoparticles (TiO2 hybrid composites). JACS Communication 131(17), 6040-6041. (First report of SERS phenomenon using a metal oxide nanoparticle rather than metal nanoparticle).

    Osman AF, Edwards GA, Schiller TL, Andriani Y, Jack KS, Morrow IC, Halley PJ, Martin DJ. (2011) Structure-property Relationships in Biomedical Thermoplastic Polyurethane Nanocomposites. Macromolecules 45(1), 198-210.

    Deng ZJ, Mortimer G, Schiller TL, Musumeci A, Martin DJ, Minchin RF. (2010) Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology 20(45), doi:10.1088/0957-4484/20/45/455101

  • Professor Anton Middelberg, above, and PhD student Alemu Tekewe Mogus explains his research, below.
    BE (Hons) Adel, PhD Adel, MA Cantab, FIChemE FTSE
    UQ Deputy Vice-Chancellor (Research) and Vice President (Research)
    AIBN Group Leader

    Contact

    Summary

    Professor Middelberg is the Deputy Vice Chancellor (Research) at The University of Queensland, where he leads the university-wide research portfolio. He obtained his Bachelor (1989) and PhD (1993) degrees from the University of Adelaide and his Master of Arts from Cambridge (2001). After appointment as the youngest lecturer in engineering at the University of Adelaide, and a Fulbright Fellowship at UC Berkeley, he accepted a position at Cambridge University. There, he was rapidly tenured and promoted twice against quota to become the Reader in Biological Engineering. In this role he reported directly to the university’s General Board and was a member of the Governing Body of Selwyn College and a Fellow of the Cambridge-MIT Institute. In 2003, he returned to Australia as a Federation Fellow of the Australian Research Council (ARC) to progress his research into bio-inspired nanotechnology. His research into virus-like particle and nanoemulsion self-assembly has attracted more than $10million in research funding since 2003, including from the ARC, National Health and Medical Research Council (NHMRC) and the Bill and Melinda Gates Foundation. Professor Middelberg was awarded the 2010 Queensland Premier’s Fellowship (one per annum statewide) to progress his research, within the Australian Institute for Bioengineering and Nanotechnology at UQ, into low-cost rapid-response nanovaccine manufacture. He has been named by Engineers Australia as one of the 100 most influential engineers in Australia, and has received a number of awards including the Brodie and Shedden-Uhde medals of the Institution of Engineers Australia. Professor Middelberg has published more than 170 refereed papers at the interface between biology and engineering and serves in a number of editorial roles including as Editor-in-Chief of Chemical Engineering Science and as Associate Editor of Vaccine.

    Research: Biomolecular engineering

    Professor Middelberg and his team conduct research in vaccine engineering, biosurfactants and bio-inspired nanomaterials. Projects encompass new technologies for cost-effective rapid vaccine development, sustainable biosurfactant technologies and nanomedicine approaches based on fundamental understanding of bio-nano interactions. Research teams collaborate extensively nationally and internationally, with regular invitations to global events. Recent funding from the Bill & Melinda Gates Foundation is targeting low-cost vaccine solutions to Rotavirus for the developing world. Alemu Tekewe Mogus joined the group from Ethiopia to advance the project. His journey is captured in a recent video. To support the research, visit the AIBN Giving Page and click on Support One Student's Journey.

    International links

    Professor Middelberg is Editor-in-Chief of leading international journal Chemical Engineering Science. He is Associate Editor of Vaccine and an Editorial Advisory Board Member for Trends in Biotechnology. Professor Middelberg has editorial roles on the Biochemical Engineering Journal, the Journal of Microbiology and Biotechnology and Pharmaceutical Bioprocessing. He has joint publications with researchers from Tianjin University, China; Oxford and Cambridge Universities, UK; University of California Berkeley, US; KAIST, Korea; and a number of companies including Eli Lilly, Novartis and Dow. Professor Middelberg has served in scientific roles for numerous international conferences including the International Biotechnology Symposium (Daegu, South Korea, 2012); the International Small-Angle Scattering Conference (Sydney, 2012); the Asian Congress of Biotechnology (Shanghai, China, 2011); and Recovery XIV (Lake Tahoe, USA, 2010).

    Memberships, patents and funding

    Professor Middelberg is an elected a Fellow of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Institution of Chemical Engineers UK. Professor Middelberg has attracted more than $13 million in research funding since 2003 and has been named as an inventor on almost 58 patents and applications.

    Awards and plenaries

    Professor Middelberg’s invention of peptide surfactants was awarded three major prizes including the 2006 TechConnect Prize in Boston. His recent invitations include plenary lectures at the World Congress of Particle Technology in Beijing (2014); the World Congress of Chemical Engineering 9 GLS-11 in Seoul (2013); the 7th Vaccines and ISV Conference in Barcelona (2013); and the 14th Asia Pacific Confederation of Chemical Engineering Congress in Singapore (2012). He annually attends either the AIChE or ECCE meeting where, in his capacity as Editor-in-Chief of Chemical Engineering Science, he introduces the Danckwerts Award Lecturer.

    Key publications for the past five years

    Dimitrijev Dwyer M, Brech M, Yu AL, Middelberg APJ. (2014) Intensified expression and purification of a recombinant biosurfactant protein. Chem Eng Sci 105, 12-21.

    Zeng BJ, Chuan YP, O’Sullivan B, Caminschi I, Lahoud MH, Thomas R, Middelberg APJ. (2013) Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly. Small 9(22), 3736-3742 (frontispiece).

    Wibowo N, Chuan YP, Lua LHL, Middelberg APJ. (2013) Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chem Eng Sci 103, 12-20.

    Chuan YP, Rivera-Hernandez T, Wibowo N, Connors NK, Wu Y, Hughes FK, Lua LHL, Middelberg APJ. (2013) Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnol Bioeng 110(9), 2343-2351 (front cover).

    Middelberg APJ, Rivera-Hernandez T, Wibowo N, Lua LHL, Fan YY, Magor G, Chang C, Chuan YP, Good MF, Batzloff MR. (2011) A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine 29(41), 7154-7162.

  • Professor Michael Monteiro
    BSc (Hons) Griffith, PhD Griffith
    ARC Future Fellow and Group Leader

    Contact

    Telephone: +61 7 334 64164 Email: m.monteiro@uq.edu.au

    Research: Designer polymers: Synthesis of complex polymer architectures

    Professor Michael Monteiro has established an international reputation in the field of 'living' radical polymerization to create complex polymer architectures. He is now building designer polymers for various biomedical applications, including vaccines, drug delivery and stem cells. He is dedicated to translating research into commercial outcomes, with 7 PCT and provisional patents since 2005 and start-up company DendriMed Pty Ltd. He was awarded an ARC QEII Fellowship in 2004 and an ARC Future Fellowship in 2009. He has attracted ARC and NHMRC grants; and Queensland State Government funding in excess of $7 million.

    International links

    Professor Monteiro has built a strong collaboration with Professor Virgil Percec from the University of Pennsylvania to develop and understand the new SET-LRP. He has developed a collaboration with Professor Rachel O'Reilly from the University of Warwick to develop nanoreactors that mimic enzyme activity. In collaboration with Professor Eugenia Kumacheva from the University of Toronto, they developed temperature responsive micron-sized particles from encapsulation of cells.

    Memberships, funding and patents

    • Editorial Advisory Boards: Biomacromolecules (ACS Journal) (2013- ), Macromolecules (ACS Journal) (2008-2010), Journal of Polymer Science Part A Polymer Chemistry (2009-)
    • ARC Funding: DP120100973 Prof MJ Monteiro; Dr TP Munro, On-demand scaffolds for directed stem cell differentiation
    • Selected Patents: (i) Release Media Prov. AU2012902396, (ii) Polymeric dendrimers for siRNA delivery Prov. AU2012903138

    Awards and plenaries

    2013 UNESCO, Stellenbosch, SA Plenary
    2013 ACS, New Orleans., USA – Invited lecture
    2013 IPCG, Shanghi, China, Invited and Co-chair
    2012 Australian Polymer Symposium, Hobart, Keynote
    2012 IUAPC POC14, Qatar, Keynote
    2011 Australian Leadership Award (ADC)

    Key publications for the past five years

    Jia ZF, Lonsdale DE, Kulis J, Monteiro MJ. (2012) Construction of a 3-Miktoarm Star from Cyclic Polymers. Acs Macro Letters 1(6), 780-783.

    Kessel S, Urbani CN, Monteiro MJ. (2011) Mechanically Driven Reorganization of Thermoresponsive Diblock Copolymer Assemblies in Water. Angew Chemie - Int Ed 50(35), 8082-8085.

    Deng ZJ, Liang MT, Monteiro MJ, Toth I, Minchin RF. (2011) Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nature Nanotechnology 6(1), 39-44.

    Bell CA, Bernhardt PV, Monteiro MJ. (2011) A Rapid Electrochemical Method for Determining Rate Coefficients for Copper-Catalyzed Polymerizations. J Am Chem Soc 133(31), 11944-11947.

    Skwarczynski M, Zaman M, Urbani CN, Lin IC, Jia Z, Batzloff MR, Good MF, Monteiro MJ, Toth I. (2010) Polyacrylate dendrimer nanoparticles: a self-adjuvanting vaccine delivery system. Angew Chem Int Ed 49(33), 5742-5745.

    Kulis J, Bell CA, Micallef AS, Jia Z, Monteiro MJ. (2009) Rapid, Selective, and Reversible Nitroxide Radical Coupling (NRC) Reactions at Ambient Temperature. Macromolecules 42(21), 8218-8227.

     
  • Professor Lars Nielsen

    MEngSc Denmark, PhD UQ
    Group Leader

    Contact

    Telephone: +61 7 334 63986 Email: lars.nielsen@uq.edu.au

    Research: Systems and synthetic biology

    Professor Lars Nielsen is leading the development of experimental and computational tools to analyse and design complex biological systems. His expertise in metabolic modelling and flux analysis is available nowhere else in Australia – and in few labs across the world. Professor Nielsen’s studies of biological systems as diverse as bacteria, baker's yeast, sugarcane, insects and mammals has attracted industrial partnerships with companies including Dow, Metabolix, Amyris, LanzaTech, Boeing, Virgin Australia and GE. These metabolic engineering partnerships have focussed on developing new ways of producing aviation fuel, various materials and bioactives (antibiotics, biopesticides, monoclonal antibodies). Professor Nielsen is also applying system analysis and design approaches to tissue engineering including novel strategies for generating microtissues for drug screening and using stem cells to produce red and white blood cells for transfusion.

    International links

    Professor Nielsen collaborates with some of the world’s pre-eminent metabolic engineers. A joint project with Prof Sang Yup Lee (KAIST, Korea) enabled several extended mutual visits to explore use of sugar for higher value products. A separate project focused on producing synthetic aviation fuel based on isoprenoids involves Professor Nielsen collaborating with global synthetic biotechnology company Amyris and leading isoprenoid metabolic engineer Professor Jay Keasling, from UC Berkeley. Professor Nielsen has secured $8million since 2006 from industry through research grants with US, European, Japanese, Korean, New Zealand and Australian companies.

    Memberships, patents and funding

    Professor Nielsen has been granted four patents – two in stem cells and another two in metabolic engineering. He is on the Scientific Advisory Board of InSphero (2009–), a Swiss company commercialising microtissue technology originating in the Nielsen laboratory. He is an editorial board member of ACS Synthetic Biology, Metabolic Engineering, Biotechnology Journal, Biotechnology and Bioengineering and Bioprocess and Biosystems Engineering. Professor Nielsen formed and chaired the 2005 CRC SIIB Industrial Biotechnology Panel to develop an industrial biotechnology strategy for the Australian sugar industry. He successfully lobbied for the inclusion of Industrial Biotechnology in the Queensland Biotechnology Strategic Plan 2005-2015. Since then he has served as expert advisor to government, research bodies, domestic and major international companies such as Dow Chemical, DuPont and GS Caltex. In the past decade, he has been part of successful research grant applications totalling $56 million, with $31.2 million for his own systems and synthetic biology group at AIBN.

    Awards and plenaries

    Professor Nielsen has received the UQ Foundation Research Excellence Award; and the Australian Institute of Political Science Queensland Young Tall Poppy Award. He was invited to speak at the 2010 Science at the Shine Dome Symposium on Genomics & Mathematics, Canberra; and the Australian Academy of Technical Sciences & Engineering’s National Symposium on Future-Proofing Australia.

    Key publications in the past five years

    Fearnley LG, Nielsen LK. (2012) PATHLOGIC-S: A scalable Boolean framework for modelling cellular signalling. PLoS ONE 7(8), e41977.

    de Oliveira Dal'molin CG, Quek LE, Palfreyman RW, Brumbley SM, Nielsen LK. (2010) AraGEM - a Genome-Scale Reconstruction of the Primary Metabolic Network in Arabidopsis thaliana. Plant Physiol 152, 579–589.

    Quek L-E, Dietmair S, Krömer JO, Nielsen LK. (2010) Metabolic flux analysis in mammalian cell culture. Metabolic Engineering 12, 161-171.

    Timmins NE, Palfreyman E, Marturana F, Dietmair S, Luikenga S, Lopez G, Fung YL, Minchinton R, Nielsen LK. (2009) Clinical Scale Ex vivo Manufacture of Neutrophils from Hematopoietic Progenitor Cells. Biotechnol Bioeng 104, 832-840.

    Chen W, Marcellin E, Hung J, Nielsen LK. (2009) Hyaluronan molecular weight is controlled by UDP-N- acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem 284, 18007-18014.

  • Professor Matt Trau and, below, videos describing his research. The first video was recorded by the National Breast Cancer Foundation in August 2013. The second is a NBCF webinar recorded in April 2014 and the third is an explanation of Prof Trau's research in the generic field of nanotechnology on YouTube (click to view).

    BSc (Hons) Syd, PhD (Physical Chemistry) Melb
    AIBN Deputy Director (Nanotechnology) and Group Leader

    Contact

    Telephone: +61 7 334 64173 Email: m.trau@uq.edu.au

    Research: Nanoscience, Nanotechnology, Molecular diagnostics

    Professor Matt Trau is currently a Professor of Chemistry at The University of Queensland (UQ); and is also Deputy Director and co-founder of the Australian Institute for Bioengineering and Nanotechnology. Since graduating from the University of Sydney (BSc Hons I, University Medal) and the University of Melbourne (PhD in Physical Chemistry, 1993), he has held positions in industry and academia across the globe. These include a Fulbright Research Fellowship at Princeton University, USA; and a research scientist at Dow Chemical and ICI Pty Ltd. Professor Trau has been a Visiting Professor at two of the largest Cancer Research Centres in the world: The Dana Farber
    Cancer Research Institute, Harvard Medical School, Boston (2000); and the Fred Hutchinson Cancer Research Centre, Seattle (2008). Professor Trau is internationally recognised for his innovative and cross-disciplinary research at the interface between chemistry, nanotechnology, biology and medicine. He has co-authored more than 100 refereed publications, many of which appear in the highest impact journals in his field, e.g., two Nature and two Science publications. His major awards and honours include an ARC Federation Fellowship (one of the most prestigious scientific fellowships in Australia), a Fulbright Research Fellowship to the USA; a Queensland Young Tall Poppy Award; a UQ Foundation/Vice Chancellor’s Research Excellence Award; a Paul Harris Fellowship; and a Pink Circle Award for breast cancer research excellence.

     

    Leadership of major multi-disciplinary international programs

    Professor Trau has raised more than $22 million in competitive national and international grant funding in the past 10 years. In the last five years, Professor Trau has initiated and led several large international programs that involve close collaboration between leading nanotechnologists, molecular biologists, geneticists and commercial researchers - with the goal of creating cutting edge diagnostics. These include a $4 million National and International Research Alliances Program (NIRAP) grant from the Queensland government ("International Partnership for preventative and Personalised Medicine)"; and two consecutive $5 million multidisciplinary collaborative grants from the National Breast Cancer Foundation (NBCF): "Novel strategies for Prediction and Control of Advanced Breast Cancer via Nanoscaled Epigenetic-Based Biosensors", 2008-2013; and "Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalized Breast Cancer Care", 2013-2018. These grants involve research collaborations with some of the
    highest calibre scientists in the world, e.g., Dr Lee Hartwell (2001 Nobel Laureate) from Seattle was a co-chief investigator on the NIRAP grant, and each of the NBCF grants include leading geneticists, pathologists and oncologists from across Australia and around the world. In the past five years, he has been a consultant for a range of national and international companies such as Merck, Digene, Beckman Coulter, Panbio and A.I. Scientific, as well as being the founder and Director of Nanomics BioSystems Pty Ltd (a spinoff company from his laboratory).

    Major plenary lectures and international conferences

    Since 2003, Professor Trau has presented more than 60 invited plenary/keynote lectures at major international conferences spanning the disciplines of Chemistry, Nanotechnology, Chemical Engineering, Cancer and Diagnostics. Recent examples include: the 4th International NanoBio Conference, (Seattle) 2012; the 14th International Colloid & Surface Science Conference, (Japan) 2012; "Cancer Nanotechnology" Gordon Research Conference, (USA) 2011; the WA Cancer Conference 2011; Sydney Cancer Conference, 2010. In the past 10 years, Professor Trau has played the role of conference convenor, chair, co-chair and symposium chair for 10 major international conferences. Recent examples include: immediate past chair of the 1st International Conference on BioNano Innovation, (Brisbane) 2012; co-chair of the 5th International NanoBio Conference scheduled for Brisbane in 2014.

    Selected publications from 2014

    Reviews & Commentaries

    Wee, E. J. H.; Trau, M., Enzyme catalysis: Evolution made easy, Nature Chemistry, 6, 756-757, 2014.

    Refereed Journal Articles

    Wee, E. J. H.; Trau, M., Measuring whole genome methylation via oxygen channelling chemistry, Chemical Communications, 50, 74, 10894-10896, 2014.

    Wee, E. J. H.; Rauf, S.; Shiddiky, M. J.; Dobrovic, A.; Trau, M., DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing, Clinical Chemistry, 61, 1, 2014.

    Wang, Y.; Rauf, S.; Grewal, Y. S.; Spadafora, L. J.; Shiddiky, M. J.; Cangelosi, G.; Schlücker, S.; Trau, M., Duplex microfluidic SERS detection of pathogen antigens with nanoyeast single-chain variable fragments, Analytical Chemistry, 86, 19, 9930-9938, 2014

    Vaidyanathan, R.; Shiddiky, M. J. A.; Rauf, S.; Dray, E.; Tay, Z.; Trau, M., Tunable “nano-shearing”: A physical mechanism to displace nonspecific cell adhesion during rare cell detection, Analytical Chemistry, 86, 4, 2042-2049, 2014.

    Vaidyanathan, R.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Tuneable surface shear forces to physically displace nonspecific molecules in protein biomarker detection, Biosensors and Bioelectronics, 61, 184-191, 2014.

    Vaidyanathan, R.; Rauf, S.; Dray, E.; Shiddiky, M. J. A.; Trau, M., Alternating current electrohydrodynamics induced nanoshearing and fluid micromixing for specific capture of cancer cells, Chemistry – A European Journal, 20, 13, 3724-3729, 2014.

    Sina, A. A. I.; Howell, S.; Carrascosa, L. G.; Rauf, S.; Shiddiky, M. J.; Trau, M., eMethylsorb: electrochemical quantification of DNA methylation at CpG resolution using DNA–gold affinity interactions, Chemical Communications, 50, 13153-13156, 2014.

    Sina, A. A. I.; Carrascosa, L. G.; Palanisamy, R.; Rauf, S.; Shiddiky, M. J.; Trau, M., Methylsorb: A simple method for quantifying DNA methylation using DNA-gold affinity interactions, Analytical Chemistry, 86, 20, 10179-10185, 2014.

    Shiddiky, M. J. A.; Vaidyanathan, R.; Rauf, S.; Tay, Z.; Trau, M., Molecular nanoshearing: An innovative approach to shear off molecules with AC-induced nanoscopic fluid flow, Scientific Reports, 4, 3716, 2014

    Shah, A. M.; Hill, M. M.; Shiddiky, M. J.; Trau, M., Electrochemical detection of glycan and protein epitopes of glycoprotein in serum, Analyst, 139, 22, 5970-5976, 2014.

    Rauf, S.; Shiddiky, M. J. A.; Trau, M., Electrohydrodynamic removal of non-specific colloidal adsorption at electrode interfaces, Chemical Communications, 50, 37, 4813-4815, 2014.

    Lau, H. Y.; Palanisamy, R.; Trau, M.; Botella, J. R., Molecular inversion probe: A new tool for highly specific detection of plant pathogens, PLOS ONE, 9, 10, e111182, 2014.

    Koo, K. M.; Wee, E. J. H.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Microdevices for detecting locus-specific DNA methylation at CpG resolution, Biosensors and Bioelectronics, 56, 278-285, 2014.

    Koo, K. M.; Sina, A. A. I.; Carrascosa, L. G.; Shiddiky, M. J.; Trau, M., eMethylsorb: Rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes, Analyst, 139, 23, 6178-6184, 2014

    Grewal, Y. S.; Shiddiky, M. J. A.; Spadafora, L. J.; Cangelosi, G. A.; Trau, M., Nano-yeast–scFv probes on screen-printed gold electrodes for detection of Entamoeba histolytica antigens in a biological matrix, Biosensors and Bioelectronics, 55, 417-422, 2014.

    Carrascosa, L. G.; Sina, A. A. I.; Palanisamy, R.; Sepulveda, B.; Otte, M. A.; Rauf, S.; Shiddiky, M. J. A.; Trau, M., Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation, Chemical Communications, 50, 27, 3585-3588, 2014

    New book published by the Trau lab in 2013

    Shiddiky MJA, Wee EJH, Rauf S, Trau M (Eds). (2013) Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications. New York, US. Nova Biomedical.

    Available in electronic and hardcopy from Nova Publishers, New York. Click here to view.

    Student Opportunities

    The Trau laboratory is interested in recruiting enthusiastic, high calibre students.

    Apply for an Honours project with us.

    Apply for a PhD or MPhil project with us.

     

  • Professor Ajayan Vinu

    MSc MSU India, PhD Anna India, FRSC, FFMAS
    ARC Future Fellow

    Contact

    Telephone: +61 7 334 64122 Email: a.vinu@uq.edu.au

    Research: Multifunctional nanoporous materials for energy and a clean environment

    Professor Ajayan Vinu is recognized as one of the top international researchers in the field of nanoporous materials. His research work introduced a new field of nanoporous nitrides and developed novel methods for making nanoporous materials with different textural parameters and multiple functions. He discovered numerous novel materials such as carbon nanocage, mesoporous carbon nitride, mesoporous boron nitride and boron carbon nitrides, carbon nanocoops, and silica nanocoops. This research has led to 267 papers in a high impact factor journals with more than 7600 citation and a H-index of 48. At least 18 of his papers have been cited more than 100 times (five papers have been cited more than 200 times)and 45 papers have been cited more than 50 times. Many of his works were published in top journals, including Angewandte Chemie, JACS, Advanced Materials and Advanced Functional Materials. Professor Vinu has been made a Fellow of the Royal Society of Chemistry 2014 (UK) and a Foreign Fellow of the Maharashtra Academy of Sciences 2014 (India). He has received the JSPS Senior Invitational Fellowship (2014) from the Japan Society for the Promotion of Science; Friedrich Wilhelm Bessel Research Award from the Humboldt Foundation; an Australian Research Council (ARC) Australian Future Fellowship (2010-2014); the Indian Society of Chemists and Biologists Award for Excellence (2010); the Chemical Society of Japan Award for Young Chemists (2008); and Iran’s top science prize, the Khwarizmi International Award for applied research in nanotechnology (2008). The innovative nature and commercial potential of research from his group is shown by the 18 national and international patents. He has also secured funding of more than $3.6 Million US from both industry and government funding agencies.

    International links

    Professor Vinu has a network of collaborations with researchers in 15 countries. He has a strong collaborative links with the researchers from National Institute for Materials Science (NIMS), Japan. One of the active collaborations he has is with Professors Katsuhiko Ariga and Toshiyuki Mori from NIMS, Japan, mainly on the development of novel porous nanostructures for the fuel cells and sensing. He has also developed a strong collaboration with the professors from top Korean institutions including Yonsei University, Pusan National University, EWHA Womans University, Kyungpook National University and KRICT. Professor Vinu has been honored with visiting professor positions from several Universities in India, South Korea, Japan and Saudi Arabia. He has established a strong collaborative network with universities and institutes in India, especially with Professor A.K. Tyagi from Bhabha Atomic Research Centre (BARC); Dr Lakshmi Kantam from IICT; Professor Sadhana Rayalu from the National Environmental Engineering Research Institute (NEERI); Professor R. Jayavel from Anna University; and Professor S. Sampath from the Indian Institute of Science (IISC). Professor Vinu has organised numerous international conferences and workshops. Last year, he organised the International Conference on Emerging Advanced Materials (ICEAN-2012) that attracted more than 650 participants from about 25 different countries, including 550 researchers from abroad. He will be the chair for ICEAN-2015, due to be held in Brisbane in February 2015.

    Memberships, editorial positions and lectures

    Professor Vinu is the Associate Editor of the Journal of Nanoscience and Nanotechnology and Nanosystems in Engineering and Medicine. American Scientific Publishers have appointed him Editor-in-Chief of Advanced Porous Materials. Professor Vinu is on the editorial board of several journals, including Scientific Reports, a journal of Nature Publishing Group. He is one of the International Advisory Board Members of ICBIN, Yonsei University, South Korea. His research has attracted worldwide attention and he has been invited to deliver presentations at numerous international conferences, workshops and seminars. Professor Vinu has visited institutes in more than 30 countries to deliver about 160 lectures, including 15 plenary and 18 keynote lectures at international conferences. He has delivered about 127 invited talks.

    Key publications for the past five years

    Kim J, Anand C, Talapaneni SN, You J, Aldeyab SS, Kim E, Vinu A. (2012) Catalytic Polymerization of Anthracene in a Recyclable SBA-15 Reactor with High Iron Content by a Friedel–Crafts Alkylation. Angew Chemie International Edition 51, 2859-2863.

    Datta KKR, Subba BV, Ariga RK, Vinu A. (2010) Gold Nanoparticles Embedded in Nanoporous Carbon Nitride Stabilizer for Highly Efficient Three Component Coupling Reaction. Angew Chem Intl Ed 49, 5961-5965.

    Jin X, Balasubramanian VV, Selvan ST, Sawant DP, Chari MA, Lu GQ, Vinu A. (2009) Highly Ordered Mesoporous Carbon Nitride Nanoparticles with a High Nitrogen Content: a Novel Metal-free Basic Catalyst. Angew Chemie Intl Ed 48(42), 7884-7887.

    Alam S, Anand C, Ariga K, Mori T, Vinu A. (2009) Unusual Magnetic Properties of Size-Controlled Iron Oxide Nanoparticles Grown in a Nanoporous Matrix with Tunable Pores. Angew Chemie Inter Ed 48(40), 7358-7361.

    Ariga K, Vinu A, Ji Q, Ohmori O, Hill J, Acharya S, Koike J, Shiratori S. (2008) A Layered Mesoporous Carbon Sensor Based on Nanopore-Filling Cooperative Adsorption in the Liquid Phase. Angew Chem Int Ed 47, 7254-7257.

  • Professor Lianzhou Wang

    PhD, Shanghai Institute of Ceramics, Chinese Academy of Sciences, China
    ARC Future Fellow and Affiliate Group Leader

    Contact

    Telephone: +61 7 334 54218 Email: l.wang@uq.edu.au

    Research: Characterisation and application of functional nanomaterials

    Professor Lianzhou Wang has an international reputation in the characterisation and application of functional nanomaterials for use in renewable energy conversion/storage systems, including photocatalysts, rechargeable lithium batteries, and new generation solar cells. Professor Wang is an Australian Research Council (ARC) Future Fellow; and past recipient of an STA Fellowship of Japan; and an ARC Queen Elizabeth II Fellowship. He has attracted more than 12 ARC grants; two CSIRO Flagship Cluster projects; major Queensland Government funding, an CRC program and a number of UQ grants.

    International links

    Professor Wang has built strong international links and nurtured long term collaborations with several world leaders in material science, including Professor Michael Hoffmann from the California Institute of Technology; Professor Guozhong Cao from the University of Washington; Professors Takayoshi Sasaki, Jinhua Ye and Dr Kiyoshi Ozawa from the National Institute for Materials Sciences, Japan; Professor Michael Wark from Ruhr-University Bochum, Germany; and Professors Huiming Cheng, Yingchun Zhu and Can Li from the Chinese Academy of Sciences.

    Memberships, patents and funding

    As a chief investigator, Professor Wang has secured 13 ARC grants, two CSIRO Flagship Cluster projects, major Queensland Government funding, a CRC project and a number of UQ grants, totaling more than $12 million. He is co-author of 13 patents for new materials for clean energy use. Professor Wang is a member of the American Chemical Society, Institute of Chemical Engineers (IChemE) and the Australian Nanotechnology Network.

    Awards and plenaries

    Additional to Professor Wang’s ARC Future Fellowship and QEII awards, he has received the STA Fellowship of Japan; UQ Research Excellence Award; and Scopus Young Researcher Award in the Engineering and Technology category. He has delivered more than 30 plenary and invited keynote presentations at international conferences and symposia.

    Top ten publications for the past five years

    LZ Wang, T. Sasaki, Titanium Oxide Nanosheets: Graphene Analogues with Versatile Functionalities, Chemical Reviews, 2014, 114, 9455-9486.

    X. Zong, H. J. Chen, B. Seger, T. Pedersen, M. Dargusch, E. McFarland, C. Li, LZ Wang, Selective production of hydrogen peroxide and oxidation of hydrogen sulfide in an unbiased solar photoelectrochemical cell, Energy Environ. Sci., 2014, 7, 3347-3351. (selected as back cover)

    Y. Chen, DL. Ye, M. Wu, H.R. Chen, L. Zhang, J. L. Shi, LZ Wang, Break-up of two-dimensional MnO2 nanosheets promotes ultrasensitive pH-triggered theranostics of cancer, Adv. Mater., 2014, DOI: 10.1002/adma.201402572.

    DL. Ye, K. Ozawa, B. Wang, D. Hulicova-Jurcakova, J. Zou, CH Sun, LZ Wang, Capacity-controllable Li-rich cathode materials for lithium-ion batteries, Nano Energy, 2014, 6, 92-102.

    X. Zong, JF Han, B. Seger, HJ Chen, GQ Lu, Can Li, LZ Wang, An integrated Photoelectrochemical −Chemical Loop for Solar-driven Overall H2S Splitting, Angew. Chem. Int. Ed., 2014, 126, 4488-4492. (highlighted by C&E News and ChemViews) .

    B Seger, J McCray, A Mukherji, X Zong, Z Xing, LZ Wang, An n-Type to p-Type Switchable Photoelectrode Assembled from Alternating Exfoliated Titania Nanosheets and Polyaniline Layers, Angew. Chem. Int.  Ed. 2013, 52, 6400-6403.

    Y Bai, H Yu, Z Li, GQ Lu, R Amal, LZ Wang, In Situ Growth of a ZnO Nanowire Network within a TiO2 Nanoparticle Film for Enhanced Dye-Sensitized Solar Cell Performance, Advanced Materials, 2012, 24, 5850-5856.

    Mukherji, B. Seger, GQ Lu, LZ Wang, Nitrogen Doped Sr2Ta2O7 Coupled with Graphene Sheets as Photocatalysts for Increased Photocatalytic Hydrogen Production,  ACS Nano, 2011, 5 (5), pp 3483–3492

    X. Wu, GQ Lu, LZ Wang, Shell-in-Shell TiO2 Hollow Spheres Synthesized by One-Pot Hydrothermal Method for Dye-Sensitized Solar Cell Application, Energy and Environmental Science, 2011, 4, 3565-3572.

    A Mukherji, R. Marschall, A. Tanksale, CH Sun, S. Smith, GQ Lu, LZ Wang,  N-doped CsTaWO6 as a New Photocatalyst for Hydrogen Production from Water Splitting under Solar Irradiation, Advanced Functional Materials, 2011, 21(1), 126-132. (Frontispiece, highlighted in Nature Photonics, 2011, Vol.5, 265.)
  • Associate Professor Christine Wells

    BSc (Hons) UNE, PhD UQ
    Queensland Government Fellowship holder and Group Leader

    Contact 

    Telephone: +61 7 334 63853 Email: c.wells@uq.edu.au

    Research: Cellular differentiation and activation

    Associate Professor Christine Wells is an internationally recognised pioneer of genomics in its application to innate immunity and stem cell biology. She has driven programs to identify the genetic elements which define the innate immune system, contribute to the regulation of immune genes and describe the functions of new gene products. During the past decade Associate Professor Wells has made key contributions to several seminal papers that mapped out mammalian genome architecture and transcriptional complexity. Through gene-discovery programs in macrophage biology she characterized a role for the C-type lectin Mincle in host-fungal interactions, and has identified a number of novel proteins that modify inflammatory signaling. Associate Professor Wells is leading international efforts to model robustness in gene regulatory networks, driving insight into impact of genetic and environmental variables. In 2011, she established Stemformatics.org – a collaborative hub for Australian and international stem cell researchers.

    International links

    Associate Professor Wells has accepted a joint appointment as reader at the University of Glasgow’s Institute of Infection, Immunity and Inflammation, enabling her to establish translational linkages for her AIBN research into cellular differentiation and activation. She has an ongoing and senior role in the international genome consortium Functional Annotation of the Mammalian genome (FANTOM), with RIKEN Omics Sciences Centre, Yokohama, Japan. She is a member of the Canadian-led Project Grandiose, in collaboration with Dr Andras Nagy. She has close collaborations with Professor John Quackenbush from the Dana Farber Cancer Research Institute in Boston, US; Professor Winston Hide from Harvard School of Public Health; Dr Jessica Mar from Albert Einstein School of Medicine, New York; Professor Albin Sandelin, University of Copenhagen, Denmark; and Professor Michael Rehli from University Hospital Regensburg, Germany.

    Memberships and funding

    Associate Professor Wells is a member of the executive committee for the Australian Genomics and Associated Technology Association (AMATA) and will chair the society’s 2013 conference in Queensland. She is a member of the conference committee for the Lorne Genome. Associate Professor Wells is on the editorial board of Genomics (since 2012) and the open access journal Genomics, Proteomics & Bioinformatics. She has been guest editor for PLOS Genetics. Associate Professor Wells has been awarded $4.5 million in funding in the past five years, including $3 million in National Health and Medical Research Council (NHMRC), Australian Research Council (ARC) and Queensland Government grants as chief investigator.

    Awards and plenaries

    Associate Professor Wells has been invited to speak at numerous national and international conferences. She was plenary speaker at the International Mammalian Genome Conference, Kyoto, Japan in 2008; the NIH Functional Glycomics Meeting in Washington, US in 2011; and the Chinese Academy of Sciences 2013 Genomics Conference, Beijing. Associate Professor Wells was the only Australian PI invited to the 2011 Radcliffe (Harvard) Genomic think tank, which included attendees from Hopkins, Harvard, Princeton and the Scripps Institute. She is the recipient of a Queensland Government Fellowship (2013); the 2008 NHMRC Career Development Award; 2008 Griffith University Research Excellence Award; 2007 Australian Society for Medical Research (ARMR) Queensland Premier’s Award; 2008 Griffith University Pro−Vice Chancellor's Research Excellence Award for an Early Career Researcher; and the 2010 Women in Technology Biotech Research Award.

    Recent key publications

    Le Cao, Kim-Anh, Rohart, Florian, McHugh, Leo, Korn, Othmar and Wells, Christine A (2014) YuGene: A simple approach to scale gene expression data derived from different platforms for integrated analyses. Genomics, 103 4: 239-251. PDF

    FANTOM 5 consortium: (2014) Nature, 507 7493: 462-470. PDF


    Wells, Christine A., Mosbergen, Rowland, Korn, Othmar, Choi, Jarny, Seidenman, Nick, Matigian, Nicholas A., Vitale, Alejandra M. and Shepherd, Jill (2013) Stemformatics: visualisation and sharing of stem cell gene expression. Stem Cell Research, 10 3: 387-395. PDF


    Huang, Edward and Wells, Christome Anne (2014) The ground state of innate immune responsiveness is determined at the interface of genetic, epigenetic, and environmental influences. Journal of Immunology, 193 1: 13-19.   PDF

    Mason E, Mar JC, Laslett A, Pera MF, Quackenbush J, Wolvetang E, Wells CA (2014) Gene expression variability as a unifying element of the pluripotency network Stem Cell Reports 3 (2), 365-377.

    Heazlewood C, Sherrell H, Ryan J, Atkinson K, Wells CA and Fisk NM. High Incidence of Contaminating Maternal Cell Overgrowth in Human Placental Mesenchymal Stem/Stromal Cell Cultures: A Systematic Review. Stem Cells Trans MedPublished online August 25, 2014 doi:10.5966/sctm.2014-0051

  • Professor Andrew Whittaker

    BSc (Hons) UQ, PhD UQ
    ARC Australian Professorial Fellow and Group Leader

    Contact

    Telephone: +61 7 334 63885 Email: a.whittaker@uq.edu.au

    Research: Polymer chemistry, nanotechnology, photolithography, biomaterials science, magnetic resonance

    Professor Andrew Whittaker's research aims to develop innovative solutions to major health and nanotechnology challenges. He is an Australian Research Council (ARC) Australian Professorial Fellow, a Fellow of the Royal Australian Chemical Institute and a member of the ARC College of Experts. He directs research funded through more than $26 million in competitive grants since 2002. Professor Whittaker’s work in synthesis and characterisation of polymeric materials has underpinned major development programs in several key areas. In the field of materials for photolithography this has been supported by funding from leading semiconductor companies Intel, Sematech and the Dow Chemical Company. Outcomes include novel high-index resists for 193nm immersion lithography, new concepts for design of non-chemically amplified resists for EUV lithography, and more recently novel approaches to healing roughness in IC features. In the field of biomaterials science, Professor Whittaker is most active in developing novel imaging agents for MRI, and introduced a new class of 19F polymeric agents. He is an expert in the fundamentals of diffusion process in complex solids. He has an international reputation in the field of NMR and MRI of polymeric systems.

    International links

    Professor Whittaker is a member of numerous international committees of governing bodies in polymer science and technology, and is involved in organising major international conferences. He is past-president of the Pacific Polymer Federation. He has active collaborations with scientists at Nagoya Institute of Technology (NIT), Japan; Hubei University, China; the University of Nottingham, UK; IMEC, Belgium; Dow Electronic Materials, US; and the Intel Corporation, US. He has held visiting professor positions at INSA Lyon and NIT and was DICE Chair at University of Nottingham.


    Recent Publications

    UQ eSpace List of Publications by Professor Andrew Whittaker

    Xie, Fengwei, Flanagan, Bernadine M., Li, Ming, Sangwan, Parveen, Truss, Rowan W., Halley, Peter J., Strounina, Ekaterina V., Whittaker, Andrew K., Gidley, Michael J., Dean, Katherine M., Shamshina, Julia L., Rogers, Robin D. and McNally, Tony (2014) Characteristics of starch-based films plasticised by glycerol and by the ionic liquid 1-ethyl-3-methylimidazolium acetate: a comparative study. Carbohydrate Polymers, 111 841-848. PDF

    Pearce, Amanda K., Rolfe, Barbara E., Russell, Pamela J., Tse, Brian W.-C., Whittaker, Andrew K., Fuchs, Adrian V. and Thurecht, Kristofer J. (2014) Development of a polymer theranostic for prostate cancer. Polymer Chemistry, . PDF

    Zhang C., Peng H. and Whittaker A.K. (2014) NMR investigation of effect of dissolved salts on the thermoresponsive behavior of oligo(ethylene glycol)-methacrylate-based polymers. Journal of Polymer Science, Part A: Polymer Chemistry, 52 16: 2375-2385. PDF

    Ardana, Aditya, Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) PEG-based hyperbranched polymer theranostics: optimizing chemistries for improved bioconjugation. Macromolecules, 47 15: 5211-5219. PDF

    Zhang H., Zhou L., Noonan O., Martin D.J., Whittaker A.K. and Yu C. (2014) Tailoring the void size of iron oxide@carbon yolk-shell structure for optimized lithium storage. Advanced Functional Materials, 24 27: 4337-4342. PDF

    Santander-Borrego, Miriem, Green, David W., Chirila, Traian V., Whittaker, Andrew K. and Blakey, Idriss (2014) Click functionalization of methacrylate-based hydrogels and their cellular response. Journal of Polymer Science Part A: Polymer Chemistry, 52 13: 1781-1789. PDF

    Ooi H.W., Cooper S.J., Huang C.-Y., Jennins D., Chung E., Maeji N.J. and Whittaker A.K. (2014) Coordination complexes as molecular glue for immobilization of antibodies on cyclic olefin copolymer surfaces. Analytical Biochemistry, 456 1: 6-13. PDF

    Al Abdulla, Wael A., Hill, David J. T. and Whittaker, Andrew K. (2014) Photodegradation of some low-density polyethylene-montmorillonite nanocomposites containing an oligomeric compatibilizer. Journal of Applied Polymer Science, 131 18: . PDF

    Wang, Kewei, Peng, Hui, Thurecht, Kristofer J., Puttick, Simon and Whittaker, Andrew K. (2014) Biodegradable core crosslinked star polymer nanoparticles as 19F MRI contrast agents for selective imaging. Polymer Chemistry, 5 5: 1760-1771. PDF

    Rolfe, Barbara E., Blakey, Idriss, Squires, Oliver, Peng, Hui, Boase, Nathan R. B., Alexander, Cameron, Parsons, Peter G., Boyle, Glen M., Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. Journal of the American Chemical Society, 136 6: 2413-2419. PDF

    Yan, Kai, Li, Huan, Wang, Xin, Yi, Changfeng, Zhang, Quanyuan, Xu, Zushun, Xu, Haibo and Whittaker, Andrew K. (2014) Self-assembled magnetic luminescent hybrid micelles containing rare earth Eu for dual-modality MR and optical imaging. Journal of Materials Chemistry B, 2 5: 546-555. PDF

    Keen, Imelda, Cheng, Han-Hao, Yu, Anguang, Jack, Kevin S., Younkin, Todd R., Leeson, Michael J., Whittaker, Andrew K. and Blakey, Idriss (2014) Behavior of lamellar forming block copolymers under nanoconfinement: implications for topography directed self-assembly of sub-10 nm structures. Macromolecules, 47 1: 276-283. PDF

    Wang, David K., Varanasi, Srinivas, Strounina, Ekaterina, Hill, David J. T., Symons, Anne L., Whittaker, Andrew K. and Rasoul, Firas (2014) Synthesis and characterization of a novel POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications. Biomacromolecules, 15 2: 666-679. PDF

    Ooi, Huey Wen, Peng, Hui, Jack, Kevin S. and Whittaker, Andrew K. (2014) Understanding the diffusion of dextrans in 'Click' PNIPAAm hydrogels. Australian Journal of Chemistry, 67 1: 85-92. PDF

    Wang, David K., Varanasi, Srinivas, Fredericks, Peter M., Hill, David J. T., Symons, Anne L., Whittaker, Andrew K. and Rasoul, Firas (2013) FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study. Journal of Polymer Science Part A: Polymer Chemistry, 51 24: 5163-5176. PDF

    Ooi, Huey Wen, Jack, Kevin S., Peng, Hui and Whittaker, Andrew K. (2013) "Click" PNIPAAm hydrogels - a comprehensive study of structure and properties. Polymer Chemistry, 4 17: 4788-4800. PDF

    Wang, Kewei, Peng, Hui, Thurecht, Kristofer J., Puttick, Simon and Whittaker, Andrew K. (2013) pH-responsive star polymer nanoparticles: potential F-19 MRI contrast agents for tumour-selective imaging. Polymer Chemistry, 4 16: 4480-4489. PDF

    Ooi, Huey Wen, Jack, Kevin S., Whittaker, Andrew K. and Peng, Hui (2013) Photo-initiated thiol-ene "click" hydrogels from RAFT-synthesized poly(N-isopropylacrylamide). Journal of Polymer Science. Part A, Polymer Chemistry, 51 21: 4626-4636. PDF

    Dargaville, Bronwin L., Vaquette, Cedryck, Rasoul, Firas, Cooper-White, Justin J., Campbell, Julie H. and Whittaker, Andrew K. (2013) Electrospinning and crosslinking of low-molecular-weight poly(trimethylene carbonate-co-L-lactide) as an elastomeric scaffold for vascular engineering. Acta Biomaterialia, 9 6: 6885-6897. PDF

  • Associate Professor Ernst Wolvetang

    BSc (Hons) U Amsterdam, PhD U Amsterdam
    Group Leader

    Contact

    Telephone: +61 7 334 63894 Email: e.wolvetang@uq.edu.au

    Research: Induced pluripotent stem cells, in vitro disease models, novel regenerative medicine approaches

    Associate Professor Ernst Wolvetang is leading the derivation of footprint-free induced pluripotent stem cells (iPSC) in Australia, with a particular focus on neuronal and cardiac disease models. He is the inaugural director of the collaborative reprogramming network Cell Reprogramming Australia and organises the only annual Australian iPSC workshop. Associate Professor Wolvetang is a chief investigator at the Australian Research Council’s Special Research Initiative in Stem Cell Science, Stem Cells Australia and two National Health and Medical Research Council (NHMRC) project grants (2013-2015).

    International links

    Associate Professor Wolvetang has international collaborations with the University of Dammam, Saudi Arabia; Utrecht University, The Netherlands; The University of Copenhagen, Denmark; and the National University of Singapore.

    Memberships, patents and funding

    Associate Professor Wolvetang serves on the editorial board of six stem cell journals; is listed inventor on four patents in stem cell research; and is the recipient of more than $2.5 million in grant funding in the past five years. He is a senior reprogramming scientist in Stem Cells Ltd, chaired the Genetic Stability of Stem Cells session at the 2007 International Society for Stem Cell Research (ISSCR) conference in Cairns and organizes, among others, the Frontiers in Reprogramming conference.

    Awards and plenaries

    Associate Professor Wolvetang has given 25 lectures and was invited speaker at 23 platform meetings, including two keynote addresses. He spoke at the International Society for Stem Cell Research (ISSCR) conference in Toronto, Canada in 2006; and the 2nd Annual World Congress of Regenerative Medicine & Stem Cell in Dalian, China in 2009. Associate Professor Wolvetang organised a master-class on iPS cells at The 2nd Annual World Stem Cells & Regenerative Medicine Congress in Seoul, Korea in 2010.

    Key publications for the past five years

    Wolvetang E, Herszfeld D, Langton-Bunker E, Chung T, Filipczyk A, Houssami S, Koh K, Laslett AL, Michalska A, Nguyen L, Reubinoff BE, Tellis I, Auerbach JM, Ording CJ, Looijenga LHJ, Pera MF. (2006) CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat Biotech 24(3), 351-357.

    Chung T-L, Brena RM, Kolle G, Grimmond SM, Berman BP, Laird PW, Pera MF, Wolvetang EJ. (2010) Vitamin C promotes widespread yet specific demethylation of the hESC epigenome. Stem Cells 28(10), 1848-1855.

    Chen YS, Pelekanos RA, Ellis RL, Horne R, Wolvetang EJ, Fisk NM. (2011) Small Molecule Mesengenic Induction of Human Induced Pluripotent Stem Cells to Generate Mesenchymal Stem/ Stromal Cells. Stem cells Translational Medicine 1, 83-95.

    Nayler SP, Gatei M, Kozlov S, Gatti R, Mar JC, Wells CA, Lavin M, Wolvetang EJ. (2012) Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem cells Translational Medicine 1, 523-535.

    Briggs JA, Sun J, Shepherd J, Ovchinnikov DA, Chung TL, Nayler SP, Kao LP, Morrow CA, Thakar NY, Soo SY, Peura T, Grimmond SM, Wolvetang EJ. (2012) Integration-free iPS cells identify genetic and neural developmental features of Down syndrome etiology. Stem Cells 31(3), 467-478.

    Briggs JA, Mason E, Ovchinnikov DA, Wells CA, Wolvetang EJ. (2012) New paradigms for Down syndrome research using iPSCs: tackling complex human genetic disease. Stem Cells Translational Medicine 2(3), 175-184.

  • Professor Michael Yu

    BSc ECNU, PhD Fudan
    ARC Future Fellow and Group Leader

    Contact

    Telephone: +61 7 3346 3283 Email: c.yu@uq.edu.au

    Research: Applied functional nanomaterials

    Professor Chengzhong (Michael) Yu is an internationally recognised expert in materials science. He is an Australian Research Council (ARC) Future Fellow; a referee for more than 50 international journals; and a reviewer for the ARC and National Health and Medical Research Council (NHMRC).

    International links

    Professor Yu has collaborations with scientists in chemistry, material science and chemical engineering from the US, Japan, Scotland, Sweden, France and China. Through these collaborations, more than 30 international journal papers have been published.

    Memberships, patents and funding

    Since he joined AIBN in 2010, Professor Yu has attracted four ARC grants and funding from Cancer Council Queensland; and the Queensland Government’s Research Partnership Project, with a total of more than $6.2 million in three years. Before he joined AIBN, he attracted 12 grants from the National Science Foundation of China; the Chinese Ministry of Science and Technology; the Chinese Education Ministry; and Shanghai Government. Professor Yu is a referee for more than 50 international journals. He is a reviewer for the ARC and NHMRC; and a grants peer review panel member for the NHMRC in 2012.

    Awards and plenaries

    Professor Yu is an ARC Future Fellow (2009). He is the recipient of the 2009 Innovation Award of the Chemistry Academy of China; the 2009 Young Scientist Award of the Ceramic Society of China; the 2005 New Century Scientist Award from the Chinese Ministry of Education; and the 2004 Young Scientist Award from the Chemistry Academy of China. Professor Yu received the National Excellent Doctoral Dissertation Award in China (2004); the second prize of the National Science Award of China (2004); and the Shanghai Science & Technology Progress Award (2002). He has been invited to give more than 30 plenary, keynote and invited talks.

    Key publications for the past five years

    Niu YT, Yu MH, Hartono SB, Yang J, Xu HY, Zhang HW, Zhang J, Zou J, Dexter A, Gu WY, Yu CZ.  (2013) Nanoparticles mimicking viral surface topography for enhanced cellular delivery. Adv Mater, 25 43: 6233-6237.

    Jarnbhrunkar S, Yu MH, Yang J, Zhang J, Shrotri A, Endo-Munoz L, Moreau J, Lu GQ, Yu CZ. (2013) Stepwise pore size reduction of ordered nanoporous silica materials at angstrom precision. J. Am. Chem. Soc. 135 23: 8444-8447.

    Yang J, Zhang HW, Yu MH, Emmanuelawati I, Zou J, Yuan ZG, Yu CZ. (2014) High-content, Well-dispersed γ-Fe2O3 Nanoparticles Encapsulated in Macroporous Silica with Superior Arsenic Removal Performance. Adv. Funct. Mater.  24(10), 1354–1363.

    Zhang HW, Zhou L, Noonan O, Martin DJ, Whittaker AK, Yu CZ. (2014) Tailoring the Void Size of Iron Oxide@Carbon Yolk-Shell Structure for Optimized Lithium Storage. Adv. Funct. Mater. 24(27), 4337–4342.

    Zhang J, Karmakar S, Yu MH, Mitter N, Zou J, Yu CZ. (2014) Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins. Small, DOI: 10.1002/smll.201401538.

  • Professor Kirill Alexandrov

    PhD EMBL
    ARC Future Fellow and Group Leader

    Contact

    Telephone: +61 7 3346 2017 Email: k.alexandrov@imb.uq.edu.au

    Research: Next-generation technologies for protein research

    Professor Kirill Alexandrov is a co-founder of successful biotechnology company Jena Bioscience and credited with establishing the Dortmund Protein Production Facility at the Max-Planck Institute. He introduced high−throughput molecular cloning technology to the UQ Protein Expression Facility. Professor Alexandrov has secured three Australian Research Council (ARC) and two National Health and Medical Research Council (NHMRC) project and program grants since 2008; and been awarded an ARC Australian Postdoctoral Fellowship and Future Fellowship.

    International links

    Professor Alexandrov is a co-founder of successful biotechnology company Jena Bioscience and has retained close collaborative links with the Dortmund Protein Production Facility at the Max-Planck Institute. He has close collaborations with Brisbane biotechnology company Bioproton LLC and Perth biotechnology company Phylogica.

    Memberships, patents and funding

    Professor Alexandrov has raised about $22 million in funding since 2008; secured three Australian Research Council and two National Health (ARC) and Medical Research Council (NHMRC) grants since 2008; and been awarded an ARC Australian Postdoctoral Fellowship and Future Fellowship. He filed six patents, including one which has reached international phase.

    Awards and plenaries

    Professor Alexandrov has received more than 30 invitations to speak at national and international conferences. They include:

    • 2011 PepTalk, US. Invited Plenary Speaker, Chair of round table discussion
    • 2011 9th Matsuyama International Symposium on Cell-Free Sciences, Japan. Invited Plenary Speaker
    • 2011 FASEB Summer Research Conferences on Protein Lipidation, Signaling, and Membrane Domains, US. Invited Plenary Speaker
    • 2011 Choroideremia disease Workshop, France. Invited Plenary Speaker
    • 2011 9th Australian Peptide Conference, Australia. Invited Plenary Speaker

    In 2004, Professor Alexandrov was awarded Germany’s highest career development fellowship, the Heisenberg Award.

    Key publications in the past five years

    Stein V. and Alexandrov K. Protease-based synthetic sensing and signal amplification. PNAS, 2014 In press,  Accepted 26.09.2014

    Kovtun O., Tillu VA., Jung WR., Leneva N., Ariotti N., Chaudhary N.,Mandyam RA, Ferguson C., Harrop SJ., Alexandrov K., Parton RG and Collins BM. Structural insights into the organisation of the cavin membrane coat complex. Dev. Cell. In press. Accepted 03.10.2014

    Martin S, Papadopulos A, Tomatis VM, Sierecki E, Malintan NT, Gormal RS, Giles N, Johnston WA, Alexandrov K, Gambin Y, Collins BM, Meunier FA.  Increased polyubiquitination and proteasomal degradation of a munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis.  Cell Rep. 2014 Oct 9;9(1):206-18

    Tnimov Z, Abankwa D, Alexandrov K. RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation. Biochem Biophys Res Commun. 2014 Oct 3;452(4):967-73. Kovtun O, Mureev S, Jung W, Kubala MH, Johnston W, Alexandrov K. (2011) Leishmania cell-free protein expression system. Methods 55(1), 58-64.

    Kovtun O, Mureev S, Johnston W, Alexandrov K. (2010) Towards the construction of expressed proteomes using a Leishmania tarentolae based cell-free expression system. PLOS One 5, e14388.

    Mureev S, Kovtun O, Nguyen UTT, Alexandrov K. (2009) Species-independent translational leaders enable the rapid development of novel cell-free expression systems. Nature Biotechnology 27, 747-752.

    *Joint appointment with UQ’s Institute for Molecular Biosciences. Visit Professor Alexandrov's IMB site here.

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